微生物酶法制备D-对羟基苯甘氨酸的研究进展  

Advances on microbial enzymatic synthesis of D-p-hydroxyphenylglycine

作　　者：李业英[1] 阚振荣[1] 朱宝成[1] 

机构地区：[1]河北大学生命科学学院微生物学,保定071002

出　　处：《生物学杂志》2003年第6期11-13,F003,共4页Journal of Biology

摘　　要：D_对羟基苯甘氨酸 (D_p_HPG)是半合成青霉素和头孢霉素的重要前体。综述了微生物酶法生产D_对羟基苯甘氨酸的方法种类及其优缺点并对酶的来源即菌种的选育方法做了总结。此外 。D-hydroxyphenylglycine was the most important precursor used for the synthesis of semisynthetic penicillin and cephalosporin.The microbial enzymatic synthesis of D-p-hydroxyphenylglycine were reviewed.The screening methods to obtain the strains which can produce D-hydantoinase and D-carbamoylase were introduced.Furthermore,the advances on genetic engineering were discussed.

关 键 词：D-对羟基苯甘氨酸 D-海因酶 D-氨甲酰水解酶 hyu基因族 

分 类 号：Q814[生物学—生物工程]