马来酸氯本那敏与7,7,8,8-四氰基对二次甲基苯醌的荷移反应  

The Charge Transfer Reaction between Chlorpheniraminum and 7,7,8,8-Tetracyanoquinodemethane

作　　者：冯宇[1] 赵凤林[1] 童沈阳[1] 

机构地区：[1]北京大学化学与分子工程学院

出　　处：《分析化学》2003年第11期1327-1329,共3页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金资助项目 (No .2 93 92 60 1)

摘　　要：以马来酸氯本那敏 (商品名扑尔敏 )作为电荷给体 ,7,7,8,8 四氰基对二次甲基苯醌 (TCNQ)作为电子受体 ,研究了它们之间形成电荷转移络合物的最佳条件。结果表明 :在丙酮介质中 ,二者于室温 (2 0℃ )下 30min即可形成 1∶2络合物 ,室温下至少稳定 2h。络合物的最大吸收波长为 84 5nm。表观摩尔吸光系数ε为4 6 3× 10 4L·mol-1·cm-1,在 0～ 6mg/L范围内符合比尔定律。方法的相对标准偏差为 1.2 % (n =10 )。对形成荷移络合物的机理进行了探讨 ;用拟定的方法对片剂样品中马来酸氯本那敏的含量进行了测定 ,结果与药典方法一致 。A spectrophotometric method for the determination of chlorpheniraminum has been developed based on the charge transfer (CT) reaction. The reaction between chlorpheniraminum and 7,7,8,8-tetracyanoquinodemethane (TCNQ) was completed in acetone medium within 30 min at room temperature. The charge transfer complex is stable at least 2 h. Beer's law is obeyed in the range of 0 similar to 6 mg/L of chlorpheniraminum. The, molar absorptivity of the complex at 845 nm was 4.63 x 10(4) L.mol(-1).cm(-1). The relative standard deviation was 1.2% (n = 10). The composition of the complex was found to be 1:2 by slope ratio and Bent-French methods. The mechanism, of reaction was investigated. The method has been applied to the determination of chlorpheniraminum in tablet with satisfactory results.

关 键 词：马来酸氯本那敏 7 7 8 8-四氰基对二次甲基苯醌 荷移反应 分光光度法 抗组胺类药物 测定 

分 类 号：O621.13[理学—有机化学]