微波辐射制备羧甲基壳聚糖研究初探  

Preparation of carboxymethyl chitosan under microwave irradiation

作　　者：关丽[1] 王燕妹[2] 李国明[3] 伍焜贤[1] 

机构地区：[1]广东药学院有机化学教研室,广东广州510240 [2]广东药学院药学系 [3]华南师范大学化学系高分子研究室,广东广州510631

出　　处：《广东药学院学报》2003年第4期307-309,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：在微波辐射下用氯乙酸对壳聚糖进行化学改性 ,探讨微波条件下 ,反应物投料比、反应时间、反应温度等对羧甲基壳聚糖产率和粘度的影响。应用红外光谱分析确认在壳聚糖上引入了羧甲基基团。当氨基葡萄糖单元与氯乙酸的摩尔比为 1∶4,反应时间为 2 0min ,反应温度为 65℃时 。The carboxymethyl chitosan was prepared from chloroacetic acid and chitosan under microwave irradiation. The effects of concentration of chloroacetic acid,treatment time and temperature on the yield and viscosity were studied. The products were analyzed by infrared spectrum. The results showed that the optimum reaction conditions were as follows: the molar ratio of glucosamine(the basic unit of chitosan) to chloroacticacid was 1∶4; the reaction temperature was 65°C; the carboxymethylation time was 20 min.

关 键 词：微波辐射 壳聚糖 羧甲基壳聚糖 制备 

分 类 号：TQ463[化学工程—制药化工]