存活素与辐射诱导的凋亡  

Survivin and radiation-induced apoptosis

作　　者：高洋[1] 

机构地区：[1]第三军医大学复合伤研究所

出　　处：《国外医学（放射医学核医学分册）》2003年第5期236-238,共3页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

摘　　要：存活素(survivin)是一种新发现的细胞内蛋白,属于抗细胞凋亡蛋白家族,在胚胎和各类肿瘤中均表达,但在除胸腺和睾丸以外的成人组织中未被发现。阐明存活素在细胞凋亡和增生中的分子机制及其作用,在抗癌治疗和抑制对机体有害的细胞凋亡方面具有重要意义。Survivin is a intracellular protein that belongs to the inhibitor of apoptosis gene family.Survivin is mostly expressed in fetal tissues and many cancer cell lines,but it is not detected in normal adult tissuses ex-pect for the thymus and testis.It is important to study the molecular mechanisms of surviving both in apopto-sisand and cell division.Furthermore,surviving would be a potential new target for the cancer therapy.

关 键 词：存活素 辐射 细胞凋亡 细胞周期 细胞增生 

分 类 号：Q51[生物学—生物化学]