动物细胞凋亡与疾病的发生  

Apoptosis of cells and development of disease in animals

作　　者：龙塔[1] 杨自军[1] 董发明[1] 董淑丽[1] 王天奇[1] 温文彦[1] 

机构地区：[1]河南科技大学动物科技学院,河南洛阳471003

出　　处：《河南科技大学学报（农学版）》2003年第3期38-40,43,共4页

基　　金：河南省自然科学基金资助项目(0311032500)

摘　　要：细胞凋亡和细胞坏死是细胞死亡的两种形式,前者属于生理性的平衡机制,后者则是由于致病因子作用下发生的病理过程。免疫系统抑制与细胞凋亡有关,在免疫系统中存在两种细胞程序性死亡,一种是在无生长因子时,Bcl-2基因调控的程序化死亡;另一种是细胞毒介导的靶细胞的程序化死亡。细胞凋亡是动物机体对病毒侵入的一种防御机制之一,当细胞凋亡和细胞增殖平衡破坏时,可引起多种疾病的发生。Apoptosis and necrosis are the two forms of cell death, the former belongs to physiological balance mechanism, the latter belongs to pathologic process caused by pathogenic factor. The inhibition of immunity system is related to apoptosis. Two forms of programmed cell death(PCD)existing in immunity system are PCD controlled by Bcl-2 gene without growth factor(DF) and PCD of target cells acted by cellulotoxic. Apoptosis is one of the defense mechanism against the virus invasion, the balance between apoptosis and proliferation of cells broken may cause many kinds of disease.

关 键 词：动物细胞凋亡 疾病 发生特点 生理性平衡机制 免疫系统 基因调控 

分 类 号：Q952[生物学—动物学]