针刺对肥胖大鼠瘦素、胰岛素和神经肽Y含量的影响  

Effect of Acupuncture on Contents of Leptin,Insulin and Neuropeptide Y in Obese Rats

作　　者：刘志诚[1] 孙凤岷 孙志[1] 洪承鈗[1] 张中成[1] 朱苗花[1] 闫润虎[1] 徐炳国[1] 

机构地区：[1]南京中医药大学,江苏南京210029 [2]南京人口管理学院,江苏南京210042

出　　处：《中国中医基础医学杂志》2003年第10期39-42,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目 ( 3 9970 92 3 )

摘　　要：目的 :探讨针刺对肥胖机体瘦素 (lepin)、胰岛素INS和神经肽Y(NPY)含量及其血脑转运的作用。方法 :观察针刺治疗前后肥胖大鼠体重、Lee’s指数、体脂及中枢和外周瘦素、INS和NPY水平的变化。结果 :肥胖大鼠体重、Lee’s指数、体脂、血中瘦素、INS和NPY以及下丘脑NPY的含量均显著高于正常大鼠 ,而下丘脑瘦素和INS含量却低于正常大鼠。针刺治疗取得良好减肥疗效的同时 ,肥胖大鼠血中瘦素、INS和NPY以及下丘脑NPY的含量均显著回降 ,而下丘脑瘦素和INS含量却显著回升。结论 :肥胖体机瘦素、INS和NPY血脑转运异常可能是产生肥胖的重要原因。针刺对肥胖机体中枢和外周瘦素、INS和NPY水平的良性调整作用可能是针刺减肥作用机制之一。Objective:It is to explore the effect of acupuncture on the contents and blood brain transport of leptin,insulin (INS) and neuropeptide Y (NPY) in obese organism.Methods:The changes of body weight,lee's index,body fat,levels of central and peripheral leptin,INS and NPY in obese rats were observed before and after acupuncture.Results:The body weight,lee's index,body fat,the contents of blood leptin,INS and NPY as well as hypothalamic NPY in the obese rats were all markedly higher than those in the normal rats,but the contents of hypothalamic Leptin and INS in obese rats were all lower than of normal rats.After acupuncture treatment the marked weight lose effect was achieved while the contents of blood leptin.INS and NPY as well as hypothalamic NPY obviously decreased,the contents of hypothalamic leptin and INS obviously increased in obese rats.Conclusion:The abnormal tramsport of blood brain barrier of leptin,INS and NPY may be an important reason for the obesity.The good regulation of acupuncture on levels of central and peripheral leptin,INS and NPY possibly were one of mechanism in the antiobesity action of acupuncture.

关 键 词：针刺疗法 肥胖 瘦素 胰岛素 神经肽Y 血脑屏障 

分 类 号：R259.892[医药卫生—中西医结合] R246.1[医药卫生—中医内科学]