注射用阿莫西林钠克拉维酸钾与氯化钠注射液配伍稳定性考察  

Study on the Stability of Amoxicillin Sodium and Clavulanate Potassium for Injection in Sodium Chloride Injection Solution

作　　者：张靖贤[1] 林自中[1] 黄鲜娇[1] 

机构地区：[1]广西医科大学附属第一医院药剂科,南宁市530021

出　　处：《中国药房》2003年第12期750-751,共2页China Pharmacy

摘　　要：目的 :为临床合理用药提供科学依据。方法 :选择5℃、25℃、37℃在3h内观察配伍液的外观、pH值 ,用高效液相色谱法测定阿莫西林钠与克拉维酸钾的含量。结果 :其稳定性与温度、日光有关。结论 :配伍液不稳定 。OBJECTIVE:To study the stability of amoxicillin sodium and clavulanate potassium for injection in sodium chloride injection solution so as to offer a scientific basis for rational use of drug in clinical practice.METHODS:The external appearance and pH values of the mixed solution were observed,and the contents of Amoxicillin sodium and Clavulanate potasˉsium were determined by HPLC method at5℃,25℃and37℃within3hours.RESULTS:The stability was related to the temperature and sunlight.CONCLUSION:The mixed solution is instable and should not be put in storage for long time.

关 键 词：注射 阿莫西林钠克拉维酸钾 氯化钠注射液 配伍 稳定性 合理用药 测定 抗生素 

分 类 号：R978.11[医药卫生—药品] R927.2[医药卫生—药学]