环加氧酶抑制剂和前列腺素受体阻断剂缓解糖尿病大鼠的痛过敏  

The relieving effect of cyclooxygenase inhibitors and prostaglandin receptor blocker on hyperalgesia of diabetic rats

作　　者：张巧俊[1] 王勇[1] 张凤[1] 于叔麒[1] 

机构地区：[1]西安交通大学第二医院神经内科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2003年第6期538-541,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省自然科学基金资助 (No.2 0 0 2C2 4 0 )

摘　　要：目的　观察环加氧酶 (COX)抑制剂和前列腺素 (PG)受体阻断剂在糖尿病大鼠痛过敏中的作用。方法　给糖尿病痛过敏大鼠后爪背部皮下注射COX抑制剂消炎痛和meloxicam ,以及EP1型PG受体阻断剂SC 192 2 0 ,测定糖尿病痛过敏大鼠的伤害性爪回缩阈值 (NPWT)和热潜伏期 (TL)的变化。结果　经典的COX抑制剂消炎痛能长时间、显著缓解糖尿病大鼠的机械性痛过敏 ;选择性环加氧酶 2 (COX 2 )抑制剂meloxicam ,可短时间缓解糖尿病大鼠的机械性痛过敏和热痛过敏 ;选择性EP1型PG受体阻断剂SC 192 2 0能显著缓解糖尿病大鼠的机械性痛过敏和热痛过敏。结论　COX抑制剂和EP1型PG受体阻断剂能缓解糖尿病大鼠的痛过敏 。Objective To observe the effects of cyclooxygenase (COX) inhibitors and prostaglandin (PG) receptor blocker on hyperalgesia of diabetic rats. Methods Nociceptive paw-withdrawal threshold (NPWT) and thermal latency (TL) of diabetic hyperalgesic rats were tested after subcutaneous injections of COX inhibitors indomethacin and meloxicam, and EP 1 PG receptor blocker SC-19220 into the dorsum of the hindpaw of the rats. Results Indomethacin, a classic inhibitor of COX, produced a significant and long-lasting relief of mechanical hyperalgesia in diabetic hyperalgesic rats. Meloxicam, a selective cyclooxygenase 2 (COX-2) inhibitor, alleviated mechanical and thermal hyperalgesia, but with a shorter duration. SC-19220, a selective EP 1 PG receptor blocker, produced significant relief of mechanical and thermal hyperalgesia. Conclusion COX inhibitors and EP 1 PG receptor blocker relieve hyperalgesia of diabetic rats, which suggests that PGs play an important role in inducing and maintaining hyperalgesia in diabatic rats.

关 键 词：环加氧酶 前列腺素 糖尿病 大鼠 痛过敏 COX PG 神经病 并发症 

分 类 号：R587.2[医药卫生—内分泌]