益气散结解毒汤对S180肉瘤抑制作用的实验研究  

Effect of Yiqisanjiejiedu decoction on sarcoma180

作　　者：李选社[1] 薛晚利[1] 张健[2] 邱根全[2] 孙喜才[2] 朱江 

机构地区：[1]西安交通大学医学院卫生微生物及免疫学教研室,陕西西安710061 [2]西安交通大学第一医院中医科,陕西西安710061 [3]陕西省肿瘤医院外科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2003年第6期613-614,626,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的　探讨益气散结解毒汤对S180肉瘤细胞体内生长的抑制作用及其作用机理。方法　给接种S180肉瘤小鼠喂饲益气散结解毒汤及注射环磷酰胺后观察抑瘤率、瘤体比、吞噬细胞吞噬率、吞噬指数、酯酶染色阳性率、E花结形成率。结果　益气散结解毒汤、环磷酰胺、益气散结解毒汤加环磷酰胺组抑瘤率分别为 :6 0 .6 2 %、4 0 .32 %、4 4 .37%。益气散结解毒汤组吞噬率、脂酶染色阳性率、E花结形成率明显高于其他各组 (P <0 .0 5 )。结论　益气散结解毒汤具有明显抑制S180肉瘤作用 ,抑瘤作用可能主要是通过提高机体的细胞免疫功能而发挥作用 。Objective To explore the effect of Yiqisanjiejiedu decoction (YQSJJDD) on sarcoma180 (S180) in vivo. Methods After mice were given YQSJJDD through stomach perfusion for 10 d, inhibiting tumor rate, ratio of tumor to body in mass, macrophage engulfing rate, engulfing exponent, acidic α-naphthyl acetate esterase positive rate(ANAE) and E-rosette forming rate(E-RFR) were tested. Results The inhibiting tumor rate of YQSJJDD group, cyclophosphamide (Cy) group and YQSJJDD+Cy group were 60.62%, 40.32%, and 44.37%, respectively. The engulfing rate of macrophage, ANAE, E-RFR in YQSJJDD group were markedly higher than those in other groups. Conclusion YQSJJDD is effective on tumor probably by enhancing cellular immunity.When combined with chemotherapy drug it may decrease the effect of inhibiting tumor.

关 键 词：益气散结解毒汤 S180肉瘤 抑制作用 免疫功能 肿瘤 细胞免疫 

分 类 号：R273[医药卫生—中西医结合] R286[医药卫生—中医肿瘤科]