从层层组装的核壳粒子到医学/生物化学诊断和药物输送  

From Layer-by-Layer Assembled Core-Shell Particles to Medical/Biochemical Diagnostics and Drug Delivery

作　　者：朱以华[1] 杨晓玲[1] 李培勇[2] 胡英[3] 

机构地区：[1]华东理工大学超细材料制备与应用教育部重点实验室,上海200237 [2]上海第二医科大学附属瑞金医院核医学科,上海200025 [3]华东理工大学化学系,上海200237

出　　处：《化学进展》2003年第6期512-517,共6页Progress in Chemistry

基　　金：国家自然科学基金资助项目 (No.2 0 2 76 0 19)

摘　　要：层层组装的核壳型粒子由于具有尺度和组成的剪裁优点近年来得到了广泛的研究 ,它们为技术应用如医学 /生物化学诊断和药物输送提供了新的机遇。本文综述了基于层层自组装和胶体模板以及采用各种化学和物理方法直接除去核制备磁性复合核壳粒子和空腔球体。给出了核壳粒子在药物输送、生物检测与标记应用的一些实例。Layer-by-layer (LbL) assembled core-shell particles are currently studied immensely due to their advantages of tailored dimensions and compositions. They have potential technological applications in areas such as medical/biochemical diagnostics and drug delivery. In this paper, the fabrication of magnetic composite core-shell particles and hollow spheres based on LbL self-assembly and colloidal templating by direct removal of core materials using a variety of chemical and physical methods are mainly reviewed. Some specific examples on the exploitation of core-shell particles in drug delivery, bioassay and biolabeling applications are given.

关 键 词：层层组装 核壳粒子 医学诊断 生物化学诊断 药物输送 空腔球体 

分 类 号：R44[医药卫生—诊断学] R914[医药卫生—临床医学]