介绍一种新的兔心脏骤停模型  

Introduction of the New Model of Sudden Cardiac Arrest of Rabbit

作　　者：王学廷[1] 赵荣坡[1] 孟丽娟[1] 王建刚[1] 李艳[1] 

机构地区：[1]河南科技大学医学院,河南洛阳471003

出　　处：《实验室研究与探索》2003年第6期53-54,共2页Research and Exploration In Laboratory

基　　金：河南省自然科学基金资助项目(编号:981170302)

摘　　要：以兔为研究对象,探讨电刺激法致心脏骤停模型建立的方法。结果电刺激致兔心脏骤停时血压骤降至2.36±0.92kPa,心电图600～700次/min室颤波;复苏后血压仍保持在较低水平,心电图S-T段持续压低;再灌注期血自由基含量较实验前显著升高(P<0.01)。表明电刺激法致兔心脏骤停模型符合心脏骤停的病理生理过程。To probe into the methods of establishing model of sudden cardiac arrest of rabbits. The result is that during the sudden cardiac arrest the blood pressure is markedly decreased to (2.36±0.92)kPa, and ECG shows the wave of ventricular fibrillation(600～700/min).After cardiacpulmonary resucitation, the blood pressure is maintained in a low level, and ECG shows lower ST segment, and MDA is increased markedly during reperfusion (P<0.01). It shows that the model of sudden condiac arrest induced by electric stimulation is unified with duration of their pathophysiology.

关 键 词：兔 心脏骤停模型 电刺激法 心电图 心脏骤停缺血 再灌注期 血自由基 动物实验 血压 

分 类 号：R541.7[医药卫生—心血管疾病]