妊高征母亲分娩的新生儿中性粒细胞减少的影响因素研究  

STUDY OF RISK FACTORS OF NEUTROPENIA IN NEONATES DELIVERED TO MOTHERS WITH PREG NANCY INDUCED HYPERTENTION

作　　者：金江[1] 宋江娥[2] 刘翠平[1] 方芳[3] 张静宵[1] 江莲[1] 曲凡[1] 徐桂芝[2] 

机构地区：[1]河北医科大学第四附属医院儿科,050011 [2]包头医学院第一附属医院儿科 [3]石家庄市第四医院产科

出　　处：《中国小儿血液》2003年第6期259-262,共4页China Child Blood

摘　　要：通过分析FL、G CSF和IL 6在妊高征相关性中性粒细胞减少的新生儿脐血中的含量变化 ,以探讨妊高征相关性新生儿中性粒细胞减少发生的危险因素。采用夹心酶联免疫吸附试验 (ELISA) ,检测妊高征母亲分娩新生儿脐血清中FL、G CSF以及IL 6的含量。结果 ,和非中性粒细胞减少组相比 ,中性粒细胞减少组脐血清中有较高水平的FL和G CSF ,两组相比有显著性差异。以中性粒细胞减少为因变量作Logistic回归分析显示 :妊高征相关性新生儿中性粒细胞减少发生的主要危险因素有胎龄和脐血清中FL的含量。结果显示 ,妊高征相关性新生儿中性粒细胞减少症的中性粒细胞数与脐血FL值呈负相关 ,早产也促进了本症的发生。临床中应当加强对妊高征分娩的胎龄较小的新生儿的监护 ,严密监测其外周血象变化 。Neutropenia is observed in 36%-57% of the neonates delive red to women with pregnancy-induced hypertention (PIH). Observations showed that this kind of neutropenia was generally transient and not due to neonates sepsis . But recently; some studies showed that such neonates might have a higher risk for nosocomial infection in the first few weeks of life. Many scholars tried to find the mechanism under this kind of neutropenia, but the exact mechanism remai ns unresolved. The aim of our study was to detect the levels of G CSF, IL 6 and FL in cord blood of neonates with PIH related neutropenia, to explore the relationships among endogenous G CSF, IL 6 and FL levels and PIH related neon ate neutropenia. Methods: FL, G CSF and IL 6 levels in the cord blood of 46 n eonates were measured by enzyme linked immunosobent assay (ELISA). And the data were analyzed with student′s t test, chi square analysis and logistic regress ion. Results: Compared with non neutropenic group, the infants with neutropenia had higher levels of FL ( t =3 210, P <0 01) and G CSF ( t =3 978, P <0.01) in their cord blood. Logistic regression with neutropenia as the de pendent variable, gestational age, birth weight, G CSF and FL levels in cord bl ood as the independent variable, demonstrated that FL level in cord blood and th e gestational age of neonates were the main risk factors for Pill related neona tal neutropenia ( b =-0 323 and 0 156 respectively, P <0 05 and <0 01 respectively, OR =0 724 and 1 169 respectively) Conclusions: PIH related neutropenia was negatively related to the level of FL in cord blood. Additionall y, preterm contributed to it. Clinically, we should pay more attention to the ne onates born to mothers with PIH, the younger the infants are, the more intensive care they need.

关 键 词：妊高征 分娩 新生儿 中性粒细胞减少 影响因素 

分 类 号：R714.7[医药卫生—妇产科学]