氯代特戊酰氯的合成方法研究  

Study on Synthetic Method of 3-Chloro-2, 2-dimethyl Propionyl Chloride

作　　者：甄小丽[1] 韩建荣[2] 李振朝[1] 张红利[1] 李丽娟 

机构地区：[1]河北科技大学理学院,河北石家庄050018 [2]南开大学化学系,天津037000

出　　处：《化学世界》2003年第12期651-652,655,共3页Chemical World

基　　金：河北省教育厅基金资助项目;(2000259)

摘　　要：以特戊酰氯为原料,采用气相反应,利用自行设计的气相反应装置,成功地实现底物β-H的气相氯代,合成了氯代特戊酰氯。并对该反应的影响因素进行探讨,研究结果表明:当氯气流速为13～15cm3/min、反应时间130min、反应温度由104.5°C升至166°C时,无须光照,产品最高收率为85%。Using a self-designed gas reactor 3-chloro-2,2-dimethyl propionyl chloride was prepared from 2, 2-dimethyl propionyl chloride and Cl2. The influence factors were investigated. The optimum reaction conditions were: in darkness; flow rate of Cl2, 13～15 cm^3/min; reaction time, 130 min and reaction temperature, from 104.5 °C to 166 °C. Under the optimum conditions the yield of the product was 85%. The structure of the product was identified by IR、~1H NMR.

关 键 词：氯代特戊酰氯 气相 氯代 合成 

分 类 号：TQ225.22[化学工程—有机化工]