通脉降脂饮合辛伐他汀治疗高脂血症临床研究  

Clinical study of Tongmaijiangzhiyin combined with Simvastatin on hyperlipidemia

作　　者：杨坚毅[1] 

机构地区：[1]广西壮族自治区柳州市中医院,柳州545001

出　　处：《河北中医》2003年第12期892-894,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的　观察通脉降脂饮合辛伐他汀治疗高脂血症临床疗效。方法　将 1 80例确诊为高脂血症患者随机分为 3组 ,通脉降脂饮组 (中药组 )、辛伐他汀组 (西药组 )、通脉降脂饮合辛伐他汀组 (中西药结合组 )各 60例 ,观察 3组治疗前后临床疗效及血脂变化 [血清总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C) ]情况。结果　 3组治疗前后血脂变化均有非常显著性差异(P <0 .0 5 ,P <0 .0 1 ) ,中西药结合组治疗后血脂改善情况与中药组、西药组比较差异不明显 (P >0 .0 5 )。中西药结合组与中药组、西药组组间临床疗效比较均有显著性差异 (P <0 .0 5 ) ,中西药结合组疗效明显优于中药组和西药组。结论　通脉降脂饮合辛伐他汀降血脂作用均明显 ,2药合用治疗高脂血症疗效佳 ,中西药结合治疗高脂血症临床前景广阔。Objective To investigate the therapeutic effect of Tongmaijiangzhiyin combined with Simvastatin on hyperlipidemia. Methods 180 cases were randomly divided into three groups, such as Tongmaijiangzhiyin group, Simvastatin group and Tongmaijiangzhiyin combined with Simvastatin group. There were 60 cases in each group. Then, to evaluate the therapeutic effect and blood lipid changes, total cholesterol, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol were observed in three groups. Results There was an obvious difference (P<0.01) of blood lipid changes between before and after treatment in each group. After treatment, the blood lipid changes in Tongmaijiangzhiyin combined with Simvastatin group had no notable discrepancy (P>0.05) compared to that of Tongmaijiangzhiyin group or Simvastatin group. The therapeutic effect of Tongmaijiangzhiyin combined with Simvastatin group was superior to that of Tongmaijiangzhiyin group and Simvastatin group (P<0.05). Conclusion Tongmaijiangzhiyin and Simvastatin both have the significant function of decreasing blood lipid, but there is the most excellent therapeutic effect on hyperlipidemia under combination.

关 键 词：高脂血症 通脉降脂饮 辛伐他汀 中西医结合疗法 

分 类 号：R589.205[医药卫生—内分泌]