用超临界CO_2法制备聚乳酸三维多孔支架材料  

Preparation of porous PLA scaffold materials by supercritical CO2 fluid technique

作　　者：张润[1] 邓政兴[1] 李立华[1] 周长忍[1] 

机构地区：[1]暨南大学生命科技学院生物材料研究室

出　　处：《材料研究学报》2003年第6期665-672,共8页Chinese Journal of Materials Research

基　　金：国家重点基础研究发展规则G1999054306;国家八六三新材料领域资助项目2001AA625050;广东省"十五"重大专项A302020104

摘　　要：在超临界CO_2(SC-CO_2)条件下制备了生物相容性良好的聚乳酸(PLA)多孔材料,研究了PLA的分子量、SC-CO_2的压力、温度和处理时间对多孔材料的结构形态、孔隙率和玻璃化温度的影响.结果表明:支架材料的孔洞分布、结构形态和孔隙率不仅与聚乳酸的分子量有关,而且与处理样品的压力、温度和时间关系密切;经超临界CO_2处理后材料的玻璃化温度(T_g)有所升高.与传统的方法所制得的材料相比较,多孔材料不仅杂质少,孔径孔率分布均匀,孔洞表面粗糙,而且在大孔之间几乎布满了直径为10～20μm的微孔.该结构提供了营养物质和新陈代谢的通道,且细胞和生长因子也能通过.In order to prepare a novel scaffold material with good biocompatibility and excellent tri-dimensional porous structure, a series of novel poly(lactic-acid)(PLA) scaffold materials were developed with supercritical carbon dioxide fluid technique (SC-CO2). The surface structure and the section structure of these scaffold materials were observed by scanning electron micrograph (SEM). The porosity and glass transition temperature (Tg) of these materials were tested. The results showed that the morphologies, porosity and Tg of these materials changed correspondingly with the change of reaction conditions. Compared with the solvent casting-salt leaching technique, The SC-CO2 technique without using organic solvent can be used to prepare porous PLA scaffold materials with excellent tri-dimensional porous structure and high porosity. And the micro-porous structures inside and outside the porous of this material are quite suitable for the cell cultivation and nutrition substance's exchanging. Such results proved that SC-CO2 technology is a promising method in preparing tissue engineering scaffold materials.

关 键 词：有机高分子材料 生物材料 超临界CO2法 聚乳酸 

分 类 号：TB324[一般工业技术—材料科学与工程]