珍珠梅提取物对肝癌初期大鼠血清一氧化氮及一氧化氮合成酶的影响  

Effect of Sorbaria sorbifolia Extract on DEN-induced Preneoplastic Hepatic of NO and NOS in Rats

作　　者：张学武[1] 孙权[1] 张良和[1] 金明[1] 

机构地区：[1]延边大学医学院,吉林延吉133000

出　　处：《时珍国医国药》2003年第12期719-720,共2页Lishizhen Medicine and Materia Medica Research

基　　金：吉林省延边朝鲜族自治州科技发展规划项目(No.2 0 0 3YBKJ0 2 7)

摘　　要：目的 :探讨珍珠梅乙酸乙酯提取物在大鼠肝脏化学致癌初期对一氧化氮 ( nitric oxide,NO)及一氧化氮合成酶( nitricoxidesynthase,NOS)的影响。方法 :按略改良 Solt- Farber氏方法制作大鼠肝脏癌前病变模型 ,用珍珠梅提取物饲养大鼠 6周后处死 ,取肝脏 ,用比色分析法检测 NO,NOS的含量。结果 :珍珠梅给药组血清 NO含量 ( μmol/ L)明显低于癌前病变模型组 ( P<0 .0 5 ) ;草苁蓉给药组血清 NOS活力 ( U/ ml)明显低于癌前病变模型组 ( P<0 .0 5 )。结论 :珍珠梅提取物可降低 NO,NOS水平 。Objective:To study the inhibitory effect of Sorbaria sorbifolia on DEN-induced preneoplastic hepatic nitric oxide and nitric oxide synthase in rats.Methods:Hepatic preneoplastic lesions in rats were induced by modified Solt-Farber protocol and the rats were killed after fed with the ethyl ester extract of Sorbaria sorbifolia for six weeks, tumor supplied group of factor was detected by using the colorimetric method.Results:The serum NO content (μmol/L) in treat group was lower than that of the model group. The serum NOS activity in treat group was lower than that of the model group.Conclusion:The Sorbaria sorbifolia can reduce the content of NO and activity of NOS, and it may be one of the anti-carcinogenic mechanisms of Sorbaria sorbifolia .

关 键 词：珍珠梅 一氧化氮 一氧化氮合成酶 

分 类 号：R285.5[医药卫生—中药学]