心疾宁胶囊对豚鼠乳头肌快反应动作电位的影响  

Effect of “Xinjining Capsule” on Fast Response Action Potential in Guinea Pig Papillary Muscle

作　　者：宋莉莉[1] 薛金贵[2] 王肖龙[2] 胡婉英[2] 林慧娟 

机构地区：[1]山东省潍坊市寒亭区人民医院,山东潍坊261100 [2]上海中医药大学附属曙光医院,上海200021 [3]山东省中医医院,山东济南250011

出　　处：《上海中医药杂志》2004年第1期52-54,共3页Shanghai Journal of Traditional Chinese Medicine

摘　　要：为研究心疾宁胶囊 (主药 :生地黄、黄连、当归、枣仁、知母等 )治疗心律失常的机理。采用标准玻璃微电极技术 ,观察正常和缺血低氧状态下 ,该药对豚鼠离体心肌乳头状肌快反应动作电位的影响 ,并与胺碘酮比较。结果 :两药均能显著延长正常心肌细胞APD5 0、APD90和ERP ;心疾宁能逆转缺血低氧引起的心肌细胞电生理改变 ,而胺碘酮无此作用。结论 :心疾宁胶囊可通过抑制钾通道 ,延长动作电位时程 。To study the mechanism of “Xinjining Capsule” in the treatment of arrhythmia, standard glass microelectrode technique was adopted to observe the effect of “Xinjining Capsule” on fast response potential in guinea pig myocardia papillary muscle under normal or ischemia-hypoxia condition and to compare with Amiodarone. Results: Normal myocardia action potential duration 50 (APD 50), action potential duration 90 (APD 90) and effective refractory period (ERP) significantly increased by “Xinjining Capsule” and Amiodarone (P< 0.01); action potential duration 20 (APD 20) increased significantly by Amiodarone (P<0.05); “Xinjining Capsule” could reverse the changes of myocardial electrophysiology resulted from ischemia-hypoxia, but Amiodarone had no such effect. It is revealed that “Xinjining Capsule” can fight arrhythmia by inhibiting K channel, prolonging action period and protecting ischemia.

关 键 词：心疾宁 胺碘酮 心脏电生理 心肌动作电位 

分 类 号：R285.5[医药卫生—中药学]