5-氟尿嘧啶毫微囊的制备  

Preparation of 5-Fluorouracil-loaded Nanocapsules

作　　者：李伟[1] 黄梅[1] 刘信安[2] 

机构地区：[1]重庆医科大学药物化学与生物材料研究室,重庆400016 [2]重庆大学环境与化学化工学院,重庆400044

出　　处：《化学世界》2004年第1期35-38,共4页Chemical World

摘　　要：采用界面聚合技术,以α-氰基丙烯酸正丁酯为载体,制备5-氟尿嘧啶毫微囊。通过扫描电镜看到毫微囊呈规则球形,测得平均粒径232±17nm(n=300),用紫外光分光光度计测得载药量为30%。体外释放实验表明微囊具有缓释特性。Nanocapsules loaded with 5-fluorouracil(5-Fu) were prepared by interfacial polymerization, with _α_-butylcyanoacrylate being chosen as carrier. The nanocapsules were uniformly spherical and the average diameter was 232 nm(_n_=300) as seen by scanning electron microscopy(SEM). The drug loading of the 5-Fu nanocapsules was 30% as tested by ultraviolet spectroscopy(UV). The behavior of drug release in vitro indicate that nanocapsules bake on sustained-release character.

关 键 词：毫微囊 5-氟尿嘧啶 氰基丙烯酸正丁酯 缓释 

分 类 号：O622[理学—有机化学]