C_(22)-二元酸单甲酯的合成  

Synthesis of C_(22)-Monomethyl Ester of Dicarboxylic Acid

作　　者：刘刚[1] 努尔买买提.阿不都克里木 吾满江.艾力 刘远凤[1] 陶敏芳[1] 

机构地区：[1]中国科学院新疆理化技术研究所

出　　处：《化学世界》2004年第1期39-41,共3页Chemical World

摘　　要：以棉籽油甲酯为原料,将非共轭的亚油酸甲酯在催化剂作用下转化共轭亚油酸甲酯,同时与富马酸发生Diels-Alder反应,生成C22-二元酸单甲酯,并采用正交实验设计探讨了投料比、温度、催化剂用量、反应时间对合成反应的影响。富马酸加入量按照n(富马酸)∶n(亚油酸甲酯)=1.1∶1投料,反应温度选择在200～210°C,催化剂碘的用量在0.3%(质量分数),反应控制在2h,转化率相对于亚油酸甲酯为98%。此工艺易于实现产业化。C_(22)-Monomethyl ester of dicarboxylic acid was synthesized from the methyl ester of cottonseed oil by converting non-conjugated methyl ester of linoleic acid to conjugated methyl ester of linoleic acid with fumaric acid via Diels-Alder reaction in the presence of catalyst. Orthogonal design was adopted to study the influences of ratio of reaction mass, reaction temperature, amount of catalys and reaction time. Optimal process conditions were obtained in the presence of iodine as follow: mote ratio of fumaric acid to methyl ester of linoleic acid was 1∶1.1; reaction temperature was 200～210(°C) and reaction time 2 h. The weight of iodine added was 3% of that of methyl ester of cottonseed oil. The conversion of the methyl ester of linoleic acid was 98%. The process can be easily carried out in industry.

关 键 词：C22-二元酸单甲酯 C22-三元酸 棉籽油甲酯 富马酸 亚油酸甲酯 

分 类 号：TQ235[化学工程—有机化工]