采集外周血造血干细胞前服用钙尔奇D对枸橼酸盐中毒的预防  

The Precaution Against the Intoxication of Citrate with Caltrate D before Peripheral Blood Stem Cells Collection

作　　者：傅强[1] 李翠萍[1] 陈津[1] 仲伟云[1] 周丽娟[1] 

机构地区：[1]南京红十字血液中心,江苏南京210008

出　　处：《中国误诊学杂志》2003年第11期1625-1626,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:比较采集外周血造血干细胞前4-5 d是否服用钙尔奇D对在采集过程中枸橼酸盐中毒的影响。方法:41例60次采集外周血造血干细胞随机分为两组。钙尔奇D组和对照组。钙尔奇D组(n=16):于外周血造血干细胞采集前4-5 d开始服用钙尔奇D600咀嚼片,1片/d。对照组(n=44):不服用钙尔奇D。在采集造血干细胞过程中,观察受试者是否出现枸橼酸盐中毒症状。结果:钙尔奇D组出现枸橼酸盐中毒症状为6.25％,明显低于对照组(84.09％,P<0.05)。结论:造血干细胞采集前4-5d服用钙尔奇D片,1片/d可明显降低造血干细胞采集过程中枸橼酸盐中毒症状的出现,保证采集过程安全、顺利地进行。Objective:To compare the effects of Caltrate D on intoxication of citrate in collecting peripheral blood stem cells. Methods: 41 volunteers were randomly divided into two groups, and 60 collecting procedures were performed. In Caltrate D group (n = 16) , all patients were administered Caltrate D600 1 tablet/day for 4-5 day before peripheral blood stem cells collection, and in control group (n = 44) > all person were not administered Caltrate D. The intoxication of citrate was observed during collecting peripheral blood stem cells procedures. Results:In collecting peripheral blood stem cells procedures, a statistical difference was found between the Caltrate D Group and Control Group (6. 25% vs 84. 09% ,P<0. 05). Conclusions:Caltrate D 1 tablet/day for 4~5 day before peripheral blood stem cells collection was able to take precaution against the intoxication of citrate and to insure the procedures safely and successfully.

关 键 词：造血干细胞 柠檬酸盐中毒 预防 钙尔奇D 

分 类 号：R135.1[医药卫生—劳动卫生]