Protective effects of vitamin B_12 , ginseng saponin, and folic acid against murine fetal deformities caused by hyperthermia  

作　　者：李荷莲 王博蔚 赵丹 韩丽英 

机构地区：[1]Department of Gynecology and Obstetrics, Second Hospital of Jilin University, Changchun 130021, China [2]Department of Gynecology and Obstetrics, First Hospital of Baotou Medical College, Baotou 014010, China

出　　处：《Chinese Medical Journal》2003年第11期1776-1778,共3页中华医学杂志（英文版）

基　　金：a grant from the National Natural Science Fundation of China (No. 39470725).

摘　　要：Objective To investigate the protective effects of vitamin B12 , ginseng saponin , and folic acid on mouse embryos subjected to high heat.Methods Mice were used for the experiment.Results After exposure of pregnant mice to high heat, the rates of teratism, stillbirth, and fetal absorption were markedly lower in mice treated with ginseng saponin and folic acid following heat exposure than in untreated mice. There were no significant differences in these rates when comparing mice treated with vitamin B12 with the untreated mice.Conclusions Ginseng saponin and folic acid can lessen injuries to murine embryos caused by high heat, while vitamin B12 has little protective effect against high temperature except for promoting overall embryonic growth.Objective To investigate the protective effects of vitamin B12 , ginseng saponin , and folic acid on mouse embryos subjected to high heat.Methods Mice were used for the experiment.Results After exposure of pregnant mice to high heat, the rates of teratism, stillbirth, and fetal absorption were markedly lower in mice treated with ginseng saponin and folic acid following heat exposure than in untreated mice. There were no significant differences in these rates when comparing mice treated with vitamin B12 with the untreated mice.Conclusions Ginseng saponin and folic acid can lessen injuries to murine embryos caused by high heat, while vitamin B12 has little protective effect against high temperature except for promoting overall embryonic growth.

关 键 词：embryo · hyperthermia ·deformity · vitamin B12·folic acid · ginseng saponin 

分 类 号：R965[医药卫生—药理学] R714.43[医药卫生—药学]