抑那通和达那唑治疗性早熟后IGF-1、IGPBP3的不同变化  

The deferent changes of insulin-like growth factor I (IGF-1) and it's binding 3 (IGFBP3) on children of precocious puberty with enantone or danazol treatment

作　　者：留佩宁[1] 项如莲[1] 游欢庆[1] 王秀娣[2] 吴丽慧[1] 金献江[1] 

机构地区：[1]温州医学院附属育英儿童医院,浙江温州325027 [2]温州医学院妇科内分泌研究室,浙江温州325027

出　　处：《儿科药学杂志》2003年第6期5-6,共2页Journal of Pediatric Pharmacy

基　　金：温州市科委课题资助项目(KW980013)

摘　　要：目的:探讨女性原发性真性性早熟(ICPP)患者的类胰岛素样生长因子(IGF鄄1)、类胰岛素样生长因子结合蛋白(IGFBP3)在不同药物治疗前后的浓度变化。方法:将18例性早熟患儿随机分成两组,A组9例使用抑那通治疗,B组9例使用达那唑治疗,测定性早熟患儿治疗前后IGF鄄1、IGFBP3值。结果:A组治疗后IGF鄄1水平较治疗前明显下降,有显著性差异(P<0.05),而B组未见明显变化(P>0.05),两组治疗前后IGFBP鄄3浓度均无显著变化(P>0.05)。结论:(1)抑那通在抑制第二性征的同时也会使GH鄄IGF鄄1轴受到抑制,而达那唑则无此抑制效应;(2)IGF鄄1的浓度可作为药物治疗后生长速率的监测指标之一。Objective: To explore the changes of concentration of serum insulin-like growth factor (IGF-1) and insulin-like growth factor binding protein Ⅲ (IGFBP-3) before and after drug treatment in patients with idiopathic central precocious puberty. Method: 18 children with precocious puberty were divided into two groups. The A group was treated with Enantone (n=9), and the B group was treated with Danazol (n=9). Result: Compared with that before treatment, the level of serum IGF-1 after treatment with Enantone was obviously descended, there was a significant difference (P < 0.05); and there was no difference in the B group between pretreatment and post-treatment (P > 0.05). The concentrations of IGFBP-3 didn't obviously change in two groups, there were no significant differences between those before and after treatment in two groups (P > 0.05). Conclusion: (1)GH-IGF-1 axis can be inhibited with enatone while the sex development was slowed down, however, Danazol hasn't such fuctions. (2)The concentration of IGF-1 can be regarded as one of the monitors over the growth velocity after treatment with drug.

关 键 词：抑那通 达那唑 药物治疗 性早熟 IGF-1 IGPBP3 类胰岛素样生长因子 类胰岛素样生长因子结合蛋白 

分 类 号：R585[医药卫生—内分泌] R977.12[医药卫生—内科学]