柴葛口服液制剂工艺研究  

Study on the processive techniques of bupleurum-puerariae oral solution by method of orthogonal test

作　　者：王刚[1] 谷容[1] 刘彬[1] 吴季俭[1] 陈运铭 

机构地区：[1]重庆医科大学附属儿童医院临床药学研究室,重庆400014 [2]重庆药友制药有限公司,重庆400020

出　　处：《儿科药学杂志》2003年第6期21-24,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨柴葛口服液的最佳提取工艺。方法:通过溶剂选择和正交设计L9(34),筛选合理的提取工艺,并制定质量控制方法。结果:最优提取工艺为A2B3C1D2,即加4倍量的水煎煮3次,每次1.5h,50%的乙醇除杂质,合并收集好的挥发油。结论:提取工艺合理,质量控制较全面。Objective: To find out the optimal extraction techniques for bupleurum-puerariae oral solution. Methods: To establish the quality control methods and optimize the extractive processes by orthogonal design L9 (34) and correct solvent. Results: The best optimum extraction condition was A2B3C1D2 that is, an amount of water four times the solution was added, and boiled three times, 1.5 h each time, with the impurities got rid of by 50% alcohol and mixed with the volatile oils at last. Conclusions: The technological process was suitable, the quality was controlled in a relatively comprehensive way. <

关 键 词：柴葛口服液 最佳提取工艺 质量控制 挥发油 正交试验 制剂学 

分 类 号：R283.6[医药卫生—中药学]