老年急性淋巴细胞白血病分子生物学改变的初步观察  

A preliminary study on the molecular biological abnormality in the elderly with acute lymphoblastic leukemia

作　　者：许家仁[1] 朱广荣[1] 

机构地区：[1]江苏省人民医院,南京210029

出　　处：《实用老年医学》2003年第6期315-316,共2页Practical Geriatrics

摘　　要：目的　研究老年急性淋巴细胞白血病 (ALL)的分子生物学特征。　 方法 　应用多聚酶链反应技术(PCR)检测了 16例老年ALL患者的bcr/abl融合基因、TCRγ基因重排 (TCRγRA)以及IgH基因重排 (IgHRA)。　 结果　 16例患者中IgHRA 11例 ,TCRγRA 4例 ,两类基因重排均阴性 1例 ;bcr/abl融合基因阳性 9例 ,阳性率 5 6 2 5 %。　 结论 　老年ALL以B ALL为多 ,bcr/abl融合基因阳性率较高 ,可能是其治疗效果较差的原因之一。Objective To study the molecular biological features in the elderly with acute lymphoblastic leukemia (ALL). Methods BCR ABL fusion transcripts and IgH, TCRγ gene rearrangement in 16 cases with ALL was detected using the polymerase chain reaction. Results Eleven of 16 cases expressed IgH gene rearrangement, 4 cases did TCRγ gene rearrangement, and one expressed neither IgH and TCRγ gene rearrangement. Nine cases (56 25%) were found to be BCR ABL positive. Conclusions B ALL is commonly found and the positive rate of BCR ABL fusion gene is high in older patients with ALL, which may be one of the causes of poor prognosis and less responsive to conventional chemotherapy.

关 键 词：急性淋巴细胞白血病 IGH基因重排 TCRΓ基因重排 BCR/ABL融合基因 老年人 分子生物学 

分 类 号：R733.71[医药卫生—肿瘤]