二硫化碳接触工人尿2-硫代噻唑烷-4-羧酸排泄规律的研究  

Urinary excretion pattern of 2-thio-thiazolidine-4-carboxylic acid in workers exposed to Carbon disulfide

作　　者：罗红[1] 李阳[1] 王凤婕[1] 陈小青[1] 谭晓东[1] 

机构地区：[1]武汉大学公共卫生学院卫生教研室,武汉430071

出　　处：《中华劳动卫生职业病杂志》2003年第6期426-428,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：教育部优秀青年教师基金资助项目 (Jyb2 0 0 10 2 )

摘　　要：目的　探讨二硫化碳 (CS2 )接触工人尿 2 硫代噻唑烷 4 羧酸 (TTCA)的排泄规律 ,为制定CS2 短时接触生物监测提供实验依据。方法　将受试对象分为 3组进行实验 :(1) 14名非CS2 接触者在某CS2 车间暴露 2h后收集不同时段尿液 ,分析其TTCA浓度变化 ;(2 )某CS2 车间 15名CS2 接触工人三班倒休息 4 8h后上班 ,连续收集 3d班前、班中、班末尿 ,分析其TTCA浓度变化 ;(3)收集 4 0名长期接触CS2 工人班末尿 ,分析其TTCA浓度变化与工人接触CS2 的 8h时间加权平均浓度 (PC TWA)的关系。结果　第 1组研究结果显示 ,接触CS2 4h后 (此时已停止接触 2h)尿中TTCA含量达到最高值 [(1.0 3± 0 .72 )mg/gCr];第 2组研究结果显示 ,班前尿TTCA含量极低 [(0 .37± 0 .2 8)mg/gCr],与班中尿 [上班后 4h(1.2 3± 0 .71)mg/gCr]及班末尿 [(1.31± 0 .78)mg/gCr]比较 ,差异有显著性 (P <0 .0 1) ,而班中尿TTCA值与班末尿相比 ,差异无显著性 (P >0 .0 5 ) ;第 3组研究结果显示 ,班末尿TTCA值与工人PC TWA之间有直线关系 [Y(TTCAmg/gCr) =1.16 36X(CS2 mg/m3) - 5 .4 116 ]。结论　班末尿TTCA值可作为CS2 接触工人的生物监测指标。Objective To study the urinary excretion pattern for of 2-thio-thiazolidine-4-carboxylic acid(TTCA) in workers exposed to CS_2,so as to provide experimental basis for working out biomonitoring measures for short-term exposure to CS_2. Methods Sixty-nine subjects were divided into three groups:(1)fourteen volunteers who had not been exposed to CS_2 before were exposed to CS_2 for 2 hours,their urine samples were collected and analyzed at different time points;(2)The urine samples of 15 occupational exposure workers were collected on pre-shift,mid-shift,post-shift;(3)The relationship between 8 h time weighted average CS_2 exposure concentrations(PC-TWA) and TTCA levels of post-shift urine was studied among 40 workers chronically exposed to CS_2. Results (1)In the 1st group,urine TTCA level reached the peak[(1.03±0.72)mg/gCr] 4 h after exposure;(2)In the 2nd group,urine TTCA level on pre-shift[(0.37±0.28)mg/gCr] was lower than that on mid-shift[(1.23±0.71) mg/gCr , P <0.01] and post-shift[(1.31±0.78)mg/gCr, P <0.01];(3)In the 3rd group,there was a linear relationship between the post-shift urine TTCA level and 8 h CS_2 exposure concentrations dose(PC-TWA).The regression equation is Y _ (TTCA mg/gCr) =1.163 6 X _ (CS_2 mg/m 3) -5.411 6. Conclusion The post-shift urine TTCA levels may be regarded as a bio-monitoring index for workers exposed to CS_2.

关 键 词：二硫化碳 接触工人 尿 2-硫代噻唑烷-4-羧酸 排泄规律 环境监测 

分 类 号：R135[医药卫生—劳动卫生]