植物源性疫苗生产中的分子生物学技术应用及发展现状  

Application of Molecular Biological Techniques and Present Situation of Development on Botanical Vaccine Production

作　　者：王志芳 

机构地区：[1]陕西省饲料厂,陕西杨陵712100

出　　处：《动物医学进展》2003年第6期31-34,共4页Progress In Veterinary Medicine

摘　　要：传统疫苗在制作、运输、存贮和使用中手续复杂、要求严格、成本高 ,且存在疫苗反应和疫苗复苏致病的可能性 ,因此无法最大限度地推广和普及。而利用微生物或动物细胞生产基因工程疫苗成本更高 ,难度更大 ,只是在对付人类一些重大疾病时才不得已而为之。如果应用分子生物学技术把重组疫苗基因导入植物 ,使其大量表达 ,生产出植物源性疫苗 ,就有望解决上述问题。植物源性疫苗一旦研制成功 ,便可通过大田栽培转基因植物而获得。人们可直接食用这种植物或其产品获得免疫力。目前已有部分植物源性疫苗在小鼠和人体上小规模实验取得成功 ,虽然植物源性疫苗的生产走上规模化道路还存在一些技术问题有待解决 ,但从长远来看 ,前景可观。Due to the Complicated processes of production,strict requirement of transportation,usage and storage,costs and possibility of vaccine reaction, the traditional vaccine is very difficult to popularize. Besides, the gene engineering vaccine obtained from microbes or animal cells is also difficult and expensive to produce,It applying molecular biological techniques to transfer recombined vaccine gene to plant produced botanical vaccine,all above problems would be solved,the people can be immunized by eating plants cultivated in fields. At present, the small scale test has already succeeded in human and animal. Although there are some technological problems need to be solved, in the long run, production of botanical vaccine has a very bright future.

关 键 词：植物源性疫苗 生产 分子生物学技术 发展现状 制作方法 运输 存贮 

分 类 号：S852.4[农业科学—基础兽医学]