复方葶苈注射液对肺心病急性发作期t-PA、PAI活性的影响  

Clinical Study on Influences of Tingli Compound Injection(复方葶苈注射液) on Activity of t- PA and PAI of Patients with Pulmonary Heart Disease in Acute Episode Period

作　　者：赵敏[1] 赵辉[1] 戎装[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海200021

出　　处：《中国中医急症》2004年第1期7-8,共2页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的观察复方葶苈注射液对肺心病急性发作期纤溶活性的影响。方法(1)临床观察部分:将肺心病急性发作期患者随机分为治疗组与对照组,治疗组予复方葶苈注射液,对照组予酚妥拉明,观察两组治疗后t-PA及PAI活性的变化;(2)动物实验部分:将大鼠随机分为中药组(予复方葶苈注射液)、西药组(予酚妥拉明)、模型组(予生理盐水)和空白对照组(予生理盐水),造模后分别予相应药物(空白对照组不造模),观察大鼠组织型纤溶酶原激活物(t-PA)及纤溶酶原激活物抑制物(PAI)活性的改变。结果复方葶苈注射液升高t-PA活性、降低PAI活性的作用与酚妥拉明相近。结论复方葶苈注射液可改善肺心病急性发作期患者纤溶活性。To observe the activation of fibred dissolving system about Tingli Compound Injection curing pulmonary heart disease in acute episode period.Methods:In the experiment section,the treatment group was compared with the controlled group,the model group and the blank one about the activation of t- PA and PAI.And in the clinical section,the treatment group was compared with the cotrolled group before and after the curing.Results:The clinical and experimental results showed that Tingli Compound Injection could improve the activity of t- PA and reduce the activation of PAI.Conclusion:Tingli Compound Injection has the effect on ameliorating the activation about fibred dissolving system.

关 键 词：复方葶苈注射液 肺心病 急性发作期 t-PA、 PAI 动物实验 纤溶活性 

分 类 号：R259.415[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]