不同给药途径对家兔阿米卡星药动学参数的影响  

Influence on pharmacokinetics of amikacin in rabbits due to different administration pathway

作　　者：陆文铨[1] 刘皋林[1] 朱才娟[1] 罗新根[1] 

机构地区：[1]中国人民解放军第二军医大学附属长征医院药学部,上海200003

出　　处：《中国临床药学杂志》2004年第1期30-31,共2页Chinese Journal of Clinical Pharmacy

摘　　要：目的 :研究肌注和鼻甲注射对家兔阿米卡星 (AMK)药动学参数的影响。方法 :8只家兔予AMK 4mg·kg-1,im ,2wk后再以鼻甲注射同等剂量的AMK ,分别于给药后不同的时间点取血。通过荧光偏振免疫法 ,测定AMK的血药浓度 ,获得不同的药动学参数。结果 :肌注和鼻甲注射AMK后 ,Ke ,cmax和AUC均无显著性差异 ,而Ka ,T1/2 (Ka) ,tmax均有显著差异 (P <0 0 0 1) ;但鼻甲注射方法的达峰浓度较肌注高。结论 :鼻甲注射AMK后吸收较肌注迅速 。AIM: To study the influence on pharmacokentics of amikacin (AMK) in rabbit due to different administration pathway, injection of muscle and turbinate. METHODS: The concentration of AMK in plasma of 8 rabbits was detected by fluorescence polarization immunoassay (FPIA) and the parametes of pharmacokinetics of different groups were obtained. RESULTS: There were significances in Ka, T 1/2(Ka) and t max and between 2 groups after injection of AMK (P<0.001),but there were no significance in Ke,c max and AUC. The peak concentration after injection of turbinate was higher than that of injection of muscle. CONCLUSION: AMK is absorbed more rapidly through injection of turbinate than through injection of muscle, but the phase of elimination between the 2 groups is similar through which we can conclude that injection of turbinate is more suitable to some patients suffering from acute nasosinusitis.

关 键 词：给药途径 阿米卡星 药动学参数 影响 

分 类 号：R96[医药卫生—药理学]