人源抗菌肽LL-37  

Human Antimicrobial Peptide LL-37

作　　者：杨应华[1,2] 马文儒[2] 郑国光[1] 吴克复[1] 

机构地区：[1]中国医学科学院血液学研究所,实验血液学国家重点实验室,天津300020 [2]海南师范学院生物系,海口571158

出　　处：《生物化学与生物物理进展》2003年第6期847-851,共5页Progress In Biochemistry and Biophysics

基　　金：天津市科技发展计划资助项目 ( 0 0 31 1 931 1 )~~

摘　　要：LL 3 7是迄今在人体中发现的抗菌肽cathelicidin家族中的唯一成员 ,也是人体内唯一的双亲性α螺旋结构的抗菌肽 .LL 3 7在人体的血液细胞和上皮细胞中广泛分布 ,具有广谱抗菌作用 .抗菌活性依赖其螺旋构象的形成 ,通过“地毯样”机制杀灭细菌 .LL 3 7有中和内毒素的作用 ,能与LPS和CD14结合 ,中和LPS的生物活性 ,还能利用formylpeptidereceptor like 1(FPRL1)作为受体介导趋化作用 ,招募免疫细胞到感染部位 ,清除病原物 .很多感染性疾病都与LL 3 7低表达或功能失活有关 .LL 3 7是一种多功能的抗菌肽 。The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the unique amphipathic alpha-helical peptide identified in humans up to date. LL-37 is not only a major protein of blood cells, but is also present in epithelial cells. This peptide has a broad spectrum of antimicrobial activity, which kills bacteria by disrupting membrane according to the 'carpet like' mechanism. LL-37 possesses the ability to bind lipopolysaccharide (LPS) and neutralizes its biological activity via its binding activities for LPS and CD14. In addition, LL-37 acts as a chemoattractant to recruit immune cells to site of infection by binding to formyl peptide receptor-like 1 FPRL1. Taken together, LL-37 is a multifunctional modulator of innate immune responses and might have the therapeutic potential for the treatment of bacterial infection and immunocompromise.

关 键 词：人源抗菌肽 LL-37 抗菌活性 趋化作用 防御反应 

分 类 号：Q511[生物学—生物化学]