吞噬凋亡细胞的机制  

Engulfment Mechanism of Apoptotic Cells

作　　者：许铭炎[1] 徐小虎[1] 

机构地区：[1]汕头大学医学院病理系,汕头515031

出　　处：《生物化学与生物物理进展》2003年第6期855-859,共5页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目 ( 30 0 70 2 91 )~~

摘　　要：被吞噬细胞吞噬是多数凋亡细胞的命运 .凋亡细胞表面膜磷脂酰丝氨酸的暴露、膜碳水化合物的改变及表面糖蛋白的重新分布和聚集导致被吞噬细胞识别与摄取 .吞噬细胞的多种受体参与吞噬过程 ,有些受体参与栓系凋亡细胞 ,有些激发巨吞饮的摄取机制 .吞噬的摄取过程因吞噬细胞和凋亡细胞的类型差异而不同 .至少有 7种线虫吞噬基因及其哺乳动物同源物组成两条部分重叠而又平行的摄取信息传导通路 .吞噬基因的突变可以改变凋亡细胞的进程 .Ingestion by phagocytes is the fate of most cells that undergo apoptosis. During apoptosis, there are many changes on the surface of apoptotic cells, including the exposure of phosphatidylserine, the alteration of membrane carbohydrates and the redistribution or clustering of glycoproteins, which are leading to recognition and uptake by phagocytes. Many engulfment receptors have been implicated and appear to be divided into two categories, involved in tethering the apoptotic cell or triggering an uptake mechanism related to macropinocytosis. The process of uptake may vary with the apoptotic and engulfing cell types. At least seven engulfment genes in C. elegans have mammalian equivalents, and represent elements of signaling pathways involved in uptake, which have been proposed to define two parallel and partially redundant pathways. The mutation of engulfment genes can change the process of apoptosis. The defections of phagocytosis can affect the body's normal immune response.

关 键 词：吞噬细胞 吞噬作用 吞噬基因 凋亡细胞 信息传导 机制 

分 类 号：Q255[生物学—细胞生物学] R329.25[医药卫生—人体解剖和组织胚胎学]