肝干细胞的可塑性和分化机理的研究进展  

Progress in Plasticity of Hepatic Stem Cells and The Mechanisms Governing Their Differentiation

作　　者：何祖平[1] 张好建[1] 汪蕴[1] 王建今[1] 丰美福[1] 

机构地区：[1]中国科学院动物研究所,生物膜与膜生物工程国家重点实验室,北京100080

出　　处：《生物化学与生物物理进展》2003年第6期864-867,共4页Progress In Biochemistry and Biophysics

基　　金：国家"十五"高技术" 86 3"计划资助项目(2 0 0 1AA2 1 6 0 51);北京市自然科学基金资助项目( 70 2 2 0 2 3)~~

摘　　要：对肝干细胞的可塑性、多向分化潜能、分化机理及其与肝癌发病机制的关系等方面进行综述 .肝干细胞是一类具有自我更新能力和多向分化潜能的细胞 .在不同的条件下 ,肝干细胞可分化为肝细胞、胆上皮细胞、胰腺细胞和肠上皮细胞 .肝干细胞的分化涉及微环境、细胞因子和细胞外基质等多种调控因素 .肝干细胞分化为成熟肝细胞受多种转录因子和信号通路的调节 。Hepatic stem cells have an ability of self-renewal and can differentiate into a wide range of cell types including hepatocytes, bile epithelial cells, pancreatic cells and intestinal epithelial cells under various conditions. There are many factors such as microenvironment, cytokines and extracellular matrix that control hepatic stem cell differentiation. Differentiation of hepatic stem cells into hepatocytes is regulated by transcription factors and signal pathways, and hepatocellular carcinoma may result from the abnormal differentiation of hepatic stem cells. The plasticity, multi-potential differentiation, the mechanisms governing hepatic stem cell differentiation, and the relationship between hepatocellular carcinoma and the differentiation of hepatic stem cells are discussed.

关 键 词：肝干细胞 可塑性 分化机理 肝细胞癌 发病机制 

分 类 号：Q254[生物学—细胞生物学] R333.4[医药卫生—人体生理学]