冠心病心绞痛患者血浆内啡肽水平与心功能的关系  

Relation of plasma β-EP levels and heart function in patients with angina pectoris

作　　者：林朝胜[1] 王雷[1] 王凯庚[1] 鲍卫东[1] 

机构地区：[1]沈阳军区总医院,辽宁沈阳市110016

出　　处：《心血管康复医学杂志》2003年第6期499-500,共2页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨冠心病心绞痛患者β-内啡呔(β-EP)的血浆水平变化规律及其与心功能变化的关系及意义。方法:观察42例冠心病心绞痛患者血浆β-EP水平和心功能指标的变化。结果:不同临床心功能分组患者β-EP水平有明显差异,心衰Ⅱ～Ⅲ组β-EP水平高于心衰Ⅰ组,分别为218.5±65.2和138.5±44.6 pg/ml。不同β-EP水平分组患者心脏彩色多普勒心功能有明显差异,β-EP水平>200pg/ml组患者的射血分数(EF)和心输出量(CO)分别为0.47±0.20％和3.47±0.201/min,β-EP水平<100pg/ml组患者分别0.62±0.14％和5.62±0.141/min;组间比较差异显著。结论:β-EP与心功能变化有相关性。β-EP水平过高是心衰的病理介质之一。β-EP监测是分析判断病情及预后的一项重要参考指标。To demonstrate the relation between plasma β-endorphin (β-EP) levels and heart function in patients with angina pectoris. Methods: A total of 42 cases with angina pectoris were divided four groups according to heart function, β-EP levels of four groups were measured. Results: The levels of β-EP were 218. 5±65. 2pg/ml in patients with Ⅲ -Ⅳ class of heart functions 138.5±44.6 pg/ml with I class of heart function(P<0. 05). The levels of LVEF and CO were (0.47±0.20)% and (3.47±0.20) L/min respectively in group with>200 pg/ml of β-EP levels; 0. 62±0.14% and 5. 62±0.14 L/min respectively in group with <100 pg/ml of p-EP levels (P<0. 05). Conclusion: The level of β-EP increase related to the heart function in patients with angina pectoris, β-EP is a pathogenic mediator of heart function. Measure β-EP possesses important value to monitor clinic disease processes.

关 键 词：冠心病 心绞痛 血浆 心功能 Β-内啡呔 Β-EP 

分 类 号：R541.4[医药卫生—心血管疾病]