核磁共振法定量测定替米考星含量  

Quantitative Determination of Tilmicosin by 1 H NMR

作　　者：王强[1] 汪茂田[1] 张志权 

机构地区：[1]河南省分析测试中心,河南郑州450002 [2]河南省大明实业有限责任公司药物化工研究所,河南郑州450002

出　　处：《分析测试学报》2003年第6期101-103,共3页Journal of Instrumental Analysis

摘　　要：用核磁共振(1HNMR)法测定了药品替米考星(tilmicosin)的含量 ,给出了完整的实验条件和注意事项 ,线性实验测得线性回归系数为0.9985 ,重复性实验测得RSD为0.327 % ,表明此方法做为一种药物的定量方法具有简单易行、结果准确的优点 ,可用做某些没有对照品的药物定量方法的补充。The quantitative determination of tilmicosin by 1 H NMR has been developed in this paper.The optimum experimental conditions and some important aspects,which should be noticed,have been described also.As a method of medical quantitative determination,its efficacy has been proved through the experiments of repeatability and linearity.This method is simple and accurate,and can be utilized the supplement for the vacancy of the quantitative determination that without reference compounds.

关 键 词：核磁共振法 定量测定 替米考星 含量 大环内酯类抗菌素 药物分析 

分 类 号：R978.15[医药卫生—药品] R917[医药卫生—药学]