缬沙坦对兔颈动脉球囊损伤后血管内膜增生的影响观察与分析  

Effect observation and analysis of valsartan on vascular intimal hyperplasia after carotid artery balloon injury of rabbit

作　　者：刘壮[1] 王文明[1] 陈刚[1] 李乃选[1] 

机构地区：[1]滨州医学院附属医院介入血管外科,256603

出　　处：《中国社区医师》2015年第3期5-5,7,共2页Chinese Community Doctors

基　　金：科研项目经关节部位血管内膜损伤修复与重塑的实验研究;课题编号:ZR2010HM091~~

摘　　要：目的:探讨缬沙坦对兔颈动脉球囊损伤后血管内膜增生的影响。方法:选择健康雄性大耳白兔42只,随机分为假手术组、对照组和缬沙坦组。以放射免疫方法对比3组的ET1、TXB2、6-keto-PCF1a,以制作弹力纤维染色、HE切片及PNCA免疫学组织分析对比3组的PNCA指数、内膜厚度、内膜截面积、管腔狭窄度。结果:对照组的ET1、TXB2最高,缬沙坦组次之,假手术组最低;缬沙坦组6-keto-PCF1a最高,假手术组次之,对照组最低;对照组的PNCA最高,缬沙坦组次之,假手术组最低;缬沙坦组的内膜厚度、内膜截面积、管腔狭窄度与PNCA均低于对照组(P<0.05)。结论:缬沙坦对ET1、TXB2均有抑制作用,对于球囊损伤后平滑肌细胞的增殖有抑制作用。Objective:To explore the effect of valsartan on vascular intimal hyperplasia after carotid artery balloon injury of rabbit. Methods:42 male rabbits were selected.They were randomly divided into the sham operation group.The control group and the valsartan group.We compared ET1,TXB2,6-keto-PCF1a of the three groups by the method of radioimmunoassay,and compared the PNCA index,intima-media thickness,intimal cross-sectional area,the degree of stenosis using elastic fiber staining,HE chip and PNCA immunohistochemical.Results:ET1,TXB2 of the control group was the highest;valsartan group was the second;sham operation group was the lowest.The 6-keto-PCF1a of valsartan group was the highest;the sham operation group was the second;the control group was the lowest.The control group of PNCA was the highest;the Valsartan group was the second;sham operation group was the lowest.In the valsartan group,endometrial thickness,intimal cross-sectional area,the degree of stenosis,PNCA were lower than those of the control group(P<0.05).Conclusion:Valsartan has inhibitory effect on ET1,TXB2,and smooth muscle cell proliferation after balloon injury.

关 键 词：缬沙坦 球囊损伤 内膜增生 

分 类 号：R965[医药卫生—药理学]