小剂量倍他乐克对老年急性心肌梗死后心室晚电位干预的研究  

The study on the interference of the Betaloc with small dosage with ventricles late potential( VLP) following elderly acute myocardial infarction( AMI)

作　　者：朱士洲[1] 张淮海[1] 孙剑平[1] 

机构地区：[1]盐城市第三人民医院心内科,江苏盐城224001

出　　处：《中国老年学杂志》2003年第12期831-832,共2页Chinese Journal of Gerontology

摘　　要：目的　探讨小剂量倍他乐克对老年急性心肌梗死 (AMI)后心室晚电位 (VLP)长期干预的作用。方法　将 1 68例老年 AMI后 VLP阳性患者随机分为两组 ,86例干预组患者服倍他乐克 6.2 5～ 2 .5 mg/次 ,2次 /d,82例对照组常规服消心痛。结果　小剂量倍他乐克干预后能使 VLP转阴 (74/86) ,使 SA- ECG的 TD- QRS、LAS较治疗前缩短 ,RMS增加 (P<0 .0 1 ) ,并有效控制室性心律失常发生。结论　小剂量倍他乐克长期干预能使老年 AMI患者 VLP转阴 ,同时又避免大剂量快速用药所致副作用。老年 AMI患者出现 VL P阳性如无明显β-阻滞剂禁忌 ,应首选小剂量倍他乐克长期治疗。Objective Objective To research the long-term interference action of the Betaloc with low dose in ventricles late potential( VLP) following elderly acute myocardial infarction( AMI).Methods 168 eldly AMI patients with VLP positive were randomly divided into two groups: interference group ( 86 cases with Betaloc 6.25~2.5mg, 2 times/d) and comparison group (82 cases with isosorbide dinitrates and aspirin).Results The Betalo of small dose could make VLP turn negative (74/86), make TD-QRS and LAS of SA-ECG shorten than those before treatment, make RMS increased remarkable (P<0.01), and it also has the efficiency of controling the occurrence of VT.Conclusions The elderly AMI patients with VLP positive but without obvious beta-blocker contraindication should choose the long-term treatment with Betaloc of low dose firstly.

关 键 词：倍他乐克 老年人 急性心肌梗死 心室晚电位 室性心律失常 

分 类 号：R972.4[医药卫生—药品] R542.22[医药卫生—药学]