5-乙炔基-4-甲基-2-硫甲基嘧啶的合成及表征  

Synthesis and characterization of 5 - ethynyl - 4 - methyl - 2 - sulfomethyl - pyrimidine

作　　者：光善仪[1] 朱维菊[1] 尹守春[1] 李村[1] 徐洪耀[1] 

机构地区：[1]安徽大学化学化工学院,安徽合肥230039

出　　处：《安徽大学学报（自然科学版）》2003年第4期78-82,共5页Journal of Anhui University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(50073001;90206014);安徽省科技厅重点基金资助项目(02022021);安徽省教育厅自然科学基金资助项目(2003kj016)

摘　　要：采用酰基化的方法合成了5-乙炔基-4-甲基-2-硫甲基嘧啶,使用傅立叶转换红外光谱、核磁共振和元素分析对分子结构进行表征。讨论和分析了反应的机制,改进了5-(1-氯乙烯)-4-甲基-2-硫甲基嘧啶的合成工艺,获得了71％的产率;使用新制的叔丁醇钾作为催化剂制备5-乙炔基-4-甲基-2-硫甲基嘧啶,在室温条件下获得了68％产率。5 - Ethynyl - 4 - methyl - 2 - sulfomethyl - pyrimidine was synthesized using acetyl-ization method and its structure was charateristized by using FT - IR, HNMR and elment analysis. The reaction mechnism was discussed and the synthetic technique of 5 - (1 - chlorovinyl) - 4 - methyl - 2 - sulfomethyl - pyrimidine was improved to attain 71 % yield. 5 - Ethynyl - 4 - methyl - 2 - sulfomethyl- pyrimidine was prepared using potassium tert - butoxide as catalyst to obtain 68% yield at room temperature.

关 键 词：5-乙炔基-4-甲基-2-硫甲基嘧啶 合成 核磁共振 傅立叶转换红外光谱 

分 类 号：O626.41[理学—有机化学]