^(131)I治疗甲亢Graves病剂量效应研究  

A Comparison of Iodine Doses in Graves' Hyperthyroidism

作　　者：侯著法[1] 姚平[1] 谭庆玲[1] 姚茂篪[1] 汪茂荣[1] 张惠[1] 

机构地区：[1]湖北民族学院附属医院内科,湖北恩施445000

出　　处：《湖北民族学院学报（医学版）》2003年第4期8-10,共3页Journal of Hubei Minzu University(Medical Edition)

摘　　要：目的　研究1 3 1 I治疗甲亢Graves病的合适剂量。方法　 4 0例既往未接受1 3 1 I治疗甲亢Graves病患者 ,随机接受以下四种1 3 1 I治疗剂量计算方法。固定低剂量 1 1 1MBq(3mCi)、固定高剂量 2 2 2MBq(6mCi)、根据 2 4h摄碘率调节后低剂量 ,1 .85MBq (5 0 μCi) /g甲状腺、根据 2 4h摄碘率调节后高剂量 3 70MBq(1 0 0 μCi) /g甲状腺。随访评估以下临床结果 :需要再次1 3 1 I治疗的甲亢、须长期服用甲状腺素的甲减、甲状腺功能正常。结果　各治疗组平均剂量相似 ,临床结果亦无显著差异。结论　用固定剂量简化了治疗程序 ,节约了治疗费用 ,值得推广。Objective To determine appropriate iodine-131 treatment doses for Graves' hyperthyroidism. Methods Patients with Graves' hyperthyroidism (n=40)who had not been previously treated with radioactive iodine were randomized to one of four dose calculation methods: low-fixed, 111 MBq(3 mCi); high-fixed, 222 MBq(6 mCi); low-adjusted, 1.85 MBq (50 μCi)/g thyroid adjusted for 24 h radioiodine uptake; and high-adjusted, 3.70 MBq(100 Ci)/g thyroid adjusted for 24 h radioiodine uptake. Subjects were followed for the following clinical outcomes: euthyroid without medication, hyperthyroid requiring further iodine, and hypothyroid requiring lifelong thyroxin. Results Mean treatment doses were similar in the different outcome groups. Clinical results showed no obvious difference.Conclusion The use of a fixed dose method simplifies the approach to treatment with potential cost savings.

关 键 词：^131I 放射治疗 甲亢 GRAVES病 剂量效应 

分 类 号：R581.1[医药卫生—内分泌] R815[医药卫生—内科学]