丙型肝炎病毒的垂直传播研究  

Vertical transmission of hepatitis C virus infection

作　　者：李珉珉[1,2] 刘叔文[3] 王珊珊[4] 王小宁[5] 

机构地区：[1]暨南大学第一附属医院 [2]第一军医大学分子免疫研究所,广东广州510515 [3]第一军医大学药物研究所 [4]广州军区军事医学研究所流行病实验室 [5]第一军医大学分子免疫研究所

出　　处：《第一军医大学学报》2003年第12期1290-1292,共3页Journal of First Military Medical University

基　　金：广东省科委资助课题(97002)~~

摘　　要：目的探讨丙型肝炎病毒(HCV)的垂直传播机制。方法选择6对抗-HCV与HCV RNA均阳性的母亲与胎儿,2对父亲抗-HCV与HCV RNA阳性、母亲阴性的胎儿为研究对象,检测父、母亲与子代HCV的感染标志,同时比较两代间所携HCV的基因型别与HCV C/E1区的序列同源性。结果6对母亲与胎儿HCV RNA阳性,基因型均一致,其中5对基因型别属Ⅱ型,1对属Ⅲ型。母亲与子代间所携HCV C/E1区的序列同源性极高,与其他母亲间、胎儿间的HCV同源性显著差异。2对父亲HCV RNA 阳性其胎儿未检测到HCV RNA。结论母亲与子代间存在出生前期的HCV的垂直传播。Objective To investigate the mechanism for vertical transmission of hepatitis C virus (HCV) infection. Methods This study included 6 pairs of mothers and fetuses who were positive for anti-HCV antibody and HCV RNA, and 2 pairs offathersandfetusinwhomthefatherwaspositiveforanti-HCVandHCVRNAwhilethemotherwasnegative.HCVgenotypes were detected by PCR and the nucleotide sequences of HCV genome spanning the core and envelope gene region (HCVC/E1)determinedandcompared.Results TheHCVgenotypesofthemothersandfetuswereconsistent.Fivemother-fetus pairs were of genotype II, 1 of genotype III, with high homology of HCV between the mothers and their ownfetuses. In contrast, in the two father-fetus pairs, no HCV RNA was detected in the fetuses in spite of the positivity of thefathers. Conclusion Vertical transmission of HCV infection from mothers to fetus is a clinical entity.

关 键 词：丙型肝炎病毒 垂直传播 检测 预防 母婴传播 父婴传播 

分 类 号：R512.6[医药卫生—内科学]