血清、腹水中AFP、CEA及CA125水平对良、恶性腹水的诊断价值  

Diagnostic Value of Serum and Ascitic Fluid AFP, CEA and CA125 Contents Determination for Differentiation of Benign From malignant Ascites

作　　者：朱焕兴[1] 杨永青[1] 

机构地区：[1]苏州市第二人民医院,215002

出　　处：《放射免疫学杂志》2003年第6期329-331,共3页Journal of Radioimmanology

摘　　要：目的 :探讨检测血清、腹水AFP、CEA及CA1 2 5对良、恶性腹水的诊断价值。方法 :放射免疫分析 86例患者血清和腹水AFP、CEA及CA1 2 5的含量。结果 :恶性腹水组血清、腹水AFP、CEA及CA1 2 5水平较之良性腹水组差异非常显著 (p <0 0 1 )。在鉴别结核、肝硬化腹水和恶性腹水时 ,以CA1 2 5≥ 5 0 0U/ml、AFP≥ 30 0ng/ml为临界值[1 ] ,可提高诊断的特异性和准确性。结论 :血清和腹水中AFP、CEA及CA1 2 5水平具有鉴别良、恶性腹水的重要意义。Objective To investigate the diagnostic value of determination of serum and ascitic fluid AFP, CEA and CA125 contents for differentiating benign from malignant ascites. Methods Serum and ascitic fluid contents of the three tumor markers were measured with RIA in 86 patients with ascites due to various causes. Results The serum and ascitic fluid AFP, CEA and CA125 levels in patients with malignant ascites were very significantly higher than those in patients with benign ascites ( p <0 01). For differentiation of benign (mainly T.B and liver cirrhosis) from malignant ascites, CA125≥500u/ml and AFP≥300ng/ml could be taken as the critical value with high cpecificity and accuracy. Conclusion Determinations of the three tumor markers levels in serum and ascitic fluid were of high value for differential diagnosis of the etiology of ascites.

关 键 词：腹水 诊断 甲胎蛋白 癌胚抗原 糖类抗原CAl25 放射免疫分析 

分 类 号：R442.5[医药卫生—诊断学] R730.6[医药卫生—临床医学]