洛赛克对高原急性缺氧胃、十二肠粘膜损害的预防效应  

Effect of Omeprazole on prevention of gastro-duodenal mucosa injury at high altitude.

作　　者：赵光斌[1] 李英悦[2] 黄跃[2] 魏凯军[2] 

机构地区：[1]四川省人民医院,四川成都610072 [2]西藏军区总医院,西藏拉萨850003

出　　处：《四川医学》2004年第1期82-83,共2页Sichuan Medical Journal

摘　　要：目的　探讨快速进入高原低氧环境中胃、十二指肠粘膜损害机理和洛赛克对急性缺氧胃、十二指肠粘膜损伤的预防效应。方法　观察乘飞机进藏的人群随机分为洛赛克组 41例 ,对照组 44例。用双盲法 ,洛赛克组进藏前 1天服用洛赛克 2 0mg/d ,连续服药 8天 ;对照组用安慰剂 (维生素B2 )。进藏后观察食欲、呕吐、腹胀、腹痛、腹泻及大便颜色 ,在进入高原第 7天查大便隐血。观察组及对照组各选无消化性溃疡 15例 ,确诊已愈合消化性溃疡 12例在进藏第 8天作胃镜检查。按规定完成观察者洛赛克组 3 8例 ,对照组 3 9例。结果　急性高原缺氧引起消化道反应 ,洛赛克组 8例( 2 1 0 5 % ) ,对照组 2 5 ( 64 10 % ) ,两组有显著性差异 (P <0 .0 0 5 ) ,其中洛赛克组出现腹痛 2例 ( 5 2 6% ) ,对照组 15例( 3 8 46% ,P <0 .0 5 )。大便隐血试验阳性 ,洛赛克组 3例 ( 7 89% ) ,对照组 16例 ( 4 1 0 3 % ) ,两组差异显著 (P <0 .0 0 5 )。胃镜检查 ,洛赛克组急性胃粘膜损害为 7 40 % ,明显低于对照组的 3 3 3 3 % (P <0 .0 1)。洛赛克组未发现溃疡复发 ,对照组溃疡复发 2例。结论　洛赛克能够有效地防止急性高原缺氧引起胃、十二肠粘膜损害 ,明显降低溃疡复发、出血、穿孔等并发症。Objective To investigate the mechanism of gastro-duodenal mucosa damage and the preventive effect of omeprazole in hypoxia environment at high altitude.Methods The people who travelled by airplane from plain to high altitude were randomly divided into group of omepraxole(n 41) and control(n 44)by double-blind method,Beginning from the day before departure,the people in the group of omeprazole took omeprazole(20 mg per day)consecutively for 8 days,whereas people in the control group took vitamin B 2. After arrival at high altitude every one was checked for epigastic fullness,pain,anorexia,diarrhea and colour of feces.7 days later, they were tested for stool occult blood.15 cases without peptic ulcer and 12 cases with recovered peptic ulcer were selected in each group for gastroscopic examination.There were 38 cases in group of omeprazole and 39 case in control who had finished all the data.Results 8 cases(21.05%)in group of omeprazole and 25 case(64.10%)in group of control had acute hypoxemia digestive tract changes,the difference between the two groups was statistically significant(P<0.005).2 cases(5.26%)had epigastralgia and 3 cases(7.89%)were stool occult blood positive in group of omeprazole and 15 cases(38.46%)had epigastralgia,and 16 cases(41.03%)were stool occult blood positive in group of control,with statistically significant difference between the two groups(P<0.005).Gastroscopic examination showed 7.40% of acute gastric mucosa injuries in group of omeprazole,which was much more lower than those of control(33.33%,P<0.01).There was no peptic ulcer recurrence in group of omeprazole but 2 cases in group of control. Conclusion Omeprazole can effectively prevent the occurrence of hypoxemic gastro-duodnal mucosa injury at high altitude and decrease the rate of g

关 键 词：高原急性缺氧 胃、十二肠粘膜损伤 洛赛克 预防 

分 类 号：R594.3[医药卫生—内科学]