银川市老年女性性激素及胰岛素水平与肥胖和血脂代谢的相关性研究  

The Association of the Levels of Sex Hormones and Insulin with Obesity and Lipid Metabolism in Ageing Female in Yinchuan City

作　　者：程羽萱 姜敏[2] 范雅洁[1] 刘旭颖[1] 田进海[2] 王嘉[2] 张旭[2] 

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院生物芯片北京国家工程研究中心宁夏分中心,银川750004

出　　处：《宁夏医科大学学报》2015年第6期646-649,共4页Journal of Ningxia Medical University

基　　金：国家自然科学基金(81160049)

摘　　要：目的研究银川市老年女性性激素水平与肥胖以及脂质代谢的相关性。方法调查486名银川市60岁以上老年女性,按腰围分为两组,腰围≥80cm的为观察组(357人),腰围<80cm的为对照组(129人),通过调查问卷的方式收集信息和进行临床检查,测量腰围;并进行实验室检查,内容包括:甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。雌二醇(E2)、睾酮(T)、促黄体生成素(LH)、促卵泡生成素(FSH)、胰岛素(INS)。结果 (1)486名老年女性中,肥胖检出率为73.46%;(2)观察组TG明显高于对照组(P<0.01);HDL-C明显低于对照组(P<0.01);(3)观察组女性的LH、FSH低于对照组(P<0.05),T、INS明显高于对照组(P<0.05)。结论肥胖与血脂代谢、性激素以及胰岛素分泌水平异常的发病率有关。Objective To investigate the association of the levels of sex hormones with obesity and lipid metabolism in ageing female in urban community of Ningxia Hui autonomous region. Methods The female subjects were recruited from Ningxia Yinchuan city and the age was over 60 years old. According to the waist circumference,subjects were divided into observation group( 357 person) and the control group( 129 person).The questionnaire was answered and the information was collected. The physical health examinations were carried out to measure their height,weight,waistline and hipline. The levels of triglyceride( TG),total cholesterol( TC),high density lipoprotein cholesterol( HDL- C),low density lipoprotein cholesterol( LDL- C),estradiol( E2),testosterone( T),luteinizing hormone( LH),follicle stimulating hormone( FSH),and insulin( INS) were measured. Results( 1) Among 486 ageing females,the detection rate of obesity was73. 46%.( 2) The lipid metabolism disorders were more observed with the ageing female whose waistline ≥80cm,compared with those ones with normal waistline. The level of TG was significantly increased and the level of HDL- C was significantly decreased among than those in the observation group than the control group;( 3) The levels of LH and FSH were significantly lower in the observation group than those in the control group; The levels of T and INS were significantly higher in the observation group than those in the control group. Conclusion The study results also show that the levels of sex hormones and insulin differ between obese and non- obese group,which indicated that there is association between secretions of sex hormone and insulin with obesity.

关 键 词：老年女性 肥胖 性激素 脂代谢 

分 类 号：R589.2[医药卫生—内分泌]