外周血白细胞计数水平与回汉民族原发性高血压的关联研究  

Relationship between WBC Count Levels and Essential Hypertension of Hui and Han Ethnic Group

作　　者：邓治中[1] 贺鹍鹏 刘贺荣[1] 强艳[2] 张伟[1] 宋辉[1] 

机构地区：[1]宁夏医科大学公共卫生学院,银川750004 [2]宁夏医科大学总医院,银川750004

出　　处：《宁夏医科大学学报》2015年第8期923-926,共4页Journal of Ningxia Medical University

基　　金：国家自然科学基金(81160110);宁夏教育厅科技项目(NGY2014090)

摘　　要：目的分析外周血白细胞(WBC)与原发性高血压(EH)之间的关系,探讨白细胞计数在回汉民族原发性高血压发生、发展中的作用。方法采用病例对照的研究方法,选择2011年10月至2012年10月在宁夏医科大学总医院及吴忠市人民医院进行体检的宁夏机关及事业单位的职工作为研究对象,449例EH患者作为病例组,655例健康人作为对照组,进行问卷调查、体格检查及实验室检测。结果病例组WBC异常率为3.3%,对照组为0.8%,病例组高于对照组(χ2=9.949,P<0.01);病例组平均白细胞计数高于对照组(t=-7.723,P<0.05);回族人群的平均WBC计数高于汉族人群(t=-4.706,P<0.001);对照组回族人群的平均WBC计数高于汉族人群(t=-4.825,P<0.01);Logistic回归分析结果显示,调整年龄、性别及民族因素前后,WBC异常组人群EH的发病风险分别是正常组人群的4.493和4.356倍(P均<0.01),WBC高水平组人群EH的发病风险分别是低水平组人群的2.251和2.237倍(P均<0.01);调整年龄、性别及EH患病因素前后,回族人群WBC水平偏高的风险分别是汉族人群的1.509和1.507倍(P均<0.01)。结论外周血WBC计数水平与EH发病风险呈正相关,低度的炎症状态可使EH的发病风险明显增高,高度炎症状态的发病风险较低度炎症状态更高,回族人群WBC计数偏高的风险高于汉族人群,其有助于宁夏回汉民族人群EH病发生、发展的预测。Objective To analyze correlation between WBC count levels and essential hypertension and to explore the effect of WBC count levels stress on the incidence of essential hypertension among Ningxia Hui and Han ethnicity. Methods Data of the medical examination of staff were collected from departments of government and collective ownership in the Affiliated Hospital of Ningxia Medical College and Wuzhong People's Hospital from October 2011 to October 2012. Case-control study was used to analyze the data. Questionnaire survey,physical examination,and laboratory test were conducted in participants. Results The abnormal level of white blood cell in EH group was 3. 3% while that of non-EH group was 0. 8% and the abnormal rate of while blood cell in EH group was significantly higher than that in the non-EH group( χ2= 9. 949,P <0. 01). The white blood cell value of EH group was significantly higher than that of non-EH group( t =-7. 723,P < 0. 05). The white blood cell value in Hui ethnicities was significantly higher than that in Han ethnic( t =-4. 706,P < 0. 01). Multi-logistic regression analysis showed that,before and after adjustment for age,gender and ethnicity,the EH risk of abnormal WBC group was respectively 4. 493 and 4. 356 times of the normal group( P all < 0. 01) while the EH risk of WBC high level group was respectively 2. 251 and2. 237 times of the low level group( P all < 0. 01). Before and after adjustment for age,gender and EH prevalent factors,the risk of the high WBC level of the Hui people was respectively 1. 509 and 1. 507 times of the Han people( P all < 0. 01). Conclusions The level of peripheral white blood cell count is significantly correlated with the pathogenesis of essential hypertension risk. Low-grade inflammatory state can make the risk of EH increased obviously. The risk of highly inflammatory state is higher than that of low-grade inflammatory state. High risk of white blood cell count level in Hui population is higher than that of Han population,which is helpful to predict the occurrence

关 键 词：白细胞计数 原发性高血压 相关性 

分 类 号：R544.1[医药卫生—心血管疾病]