三氯乙醛的毒性和致突变研究  

A Study on the Toxicity and Mutation of Trichloroacetaldehyde

作　　者：洪长福[1] 娄金萍[1] 陈钧强[1] 王洁宏[1] 周华仕[1] 吴南翔[1] 

机构地区：[1]浙江省医学科学院卫生学研究所,杭州310013

出　　处：《环境与职业医学》2003年第6期406-406,410,共2页Journal of Environmental and Occupational Medicine

摘　　要：[目的]了解三氯乙醛的毒性和致突变作用。[方法]对三氯乙醛进行急性毒性试验、致突变试验、单细胞凝胶电泳试验。[结果]雄性大鼠急性经口LD50 为1000mg/kg,雌性大鼠为681mg/kg。雄性大鼠急性经皮LD50 为1470mg/kg ,雌性大鼠为1210mg/kg。对皮肤具中等刺激性 ,对眼具中度至重度刺激性。Ames试验1mg/皿为阳性。小鼠骨髓细胞身长核试验160mg/kg时为阳性。小鼠与人淋巴细胞单细胞凝胶电泳试验为阳性。[结论]三氯乙醛属低毒级化学药物 。Objective To determine the toxicity and mutagenic effect of trichloroacetaldehyde.[Methods]Acute toxicity test,mutation test and single-cell gel electrophoresis(SCGE)were used.[Results]LD 50 for trichloroacetaldehyde by intragastric and dermal administration in male and female rats are1000mg/kg,681mg/kg and1470mg/kg,1210mg/kg,respectively.The acute skin ir-ritation test and acute eye irritation test in rabbits showed that the tested chemical has meddle irritation.The micronucleus test at a dose of160mg/kg,Ames test at1mg/plate and SCGE of lymphocytes in mice and human were positive.[Conclusion] Trichloroacetalde-hyde shows a lowtoxicity,mutation tests are positive.

关 键 词：三氯乙醛 毒性 致突变作用 单细胞凝胶电泳试验 大鼠 毒理学实验 

分 类 号：R996[医药卫生—毒理学]