快杀灵对雄性小鼠精子毒性的实验研究  被引量:4

Study on Effects of Kuaishaling on Sperm Toxicity in Mice

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作  者:甘亚平[1] 赵红刚[1] 刁路明[2] 李彩蓉[1] 

机构地区:[1]湖北咸宁医学院病理教研室,湖北咸宁437100 [2]武汉大学医学院病理教研室,武汉430071

出  处:《环境与职业医学》2003年第6期440-442,共3页Journal of Environmental and Occupational Medicine

摘  要:[目的]研究快杀灵对雄性小鼠精子的毒性作用。[方法]用不同总剂量 (9.1mg/kg、18.2mg/kg、36.4mg/kg)快杀灵给小鼠经口连续灌胃10天染毒 ,于末次染毒后25d处死小鼠 ,称重睾丸、附睾 ,并计算精子活动度、精子数及畸形率。[结果]精子数量在18.2mg/kg、36.4mg/kg组与对照组比较差异有显著性 (P<0.01)。精子畸形率在36.4mg/kg组与对照组差异有显著性 (P<0.01) ,精子活动度在3个实验组与阴性对照组差异均有显著性 (P<0.01) ,睾丸、附睾重量与阴性对照组比较 ,差异有显著性 (P<0.01)。Objective Effects of Kuaishaling at different doses on sperm toxicity in male mice were studied.[Methods] The agent was administrated to mice at different doses(9.1mg/kg,18.2mg/kg,36.4mg/kg)by gavage once a day for successive ten days.The mice were sacrificed on the35th day after following the first gavage.The weight of testicle and epididymis,the quantity,activity and morphology of sperms were examined.[Results] The spermatozoa count had significant differentce between18.2mg/kg,36.4mg/kg and control groups(P<0.01).Sperm deformation ratio had significant difference between36.4mg/kg and the negative control group(P<0.01).The spermatozoa motility changed significantly compared with the negative control group(P<0.01).Com-pared with the negative control group,significant difference in the weight of testicle and epididymis was found(P<0.01).[Conclusions] Kuaishaling has sperm toxicity to male mice.

关 键 词:快杀灵 雄性小鼠 精子活性 药物毒性 生殖功能 

分 类 号:R979.8[医药卫生—药品]

 

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