克拉霉素等三联治疗儿童幽门螺杆菌感染的临床研究  

Clinical Study of Clarithromycin Triple Therapy for Helicobacter Pylori Infection in Children

作　　者：郑淑梅[1] 孙浩平[2] 王太森[1] 刘文彬[1] 张宏伟[1] 

机构地区：[1]成都军区总医院儿科,成都610083 [2]成都军区总医院血液科,成都610083

出　　处：《成都军区医院学报》2003年第6期9-10,共2页

摘　　要：目的观察奥美拉唑(OPZ)、克拉霉素(CAM)、甲硝唑(MTN)三联短程疗法对儿童幽门螺杆茵(HP)的根除效果。方法 用电子胃镜对具有消化道症状的患儿进行胃粘膜组织形态学及13C尿素呼气试验检查。对30例HP感染的胃十二指肠炎及溃疡患儿给予CPZ、CAM、MTN治疗10天,1月后再行胃镜检查及HP检测。结果 HP根除率为93.3％,全部症状缓解或消除,药物不良反应率36.7％,但未影响治疗。结论 OPZ、CAM、MTN三联治疗儿童HP感染根除率高,临床症状改善显著,值得临床广泛使用。Objective To evaluate the therapeutic effect of omeprazole, clarithromycin and metronidazole in Helicobacter Pylori (HP) infection in children. Methods 30 patients with chronic gastroduodenitis and gastroduodenal ulcer with HP infection were treated with omeprazole,clarithromycin and metronidazole for 10 days.Gastroscopy and 13C-urea breath test(13C-UBT) were performed on these patients prior to the medication and over one month after the therapy. Results The HP eradication rate was 93.3% .The frequency of side effects was 36.7% ,but none of them led to discontinuation of the medication. Conclusions The triple therapy with omeprazole, clarithromycin and metronidazole is effective in eradicating HP infection in children and is worthy of clinical application.

关 键 词：儿童 幽门螺杆菌感染 克拉霉素 奥美拉唑 甲硝唑 药物治疗 

分 类 号：R725.7[医药卫生—儿科] R378.99[医药卫生—临床医学]