催化水解法制备单糖和无糖阿维菌素B_1  

Preparation of Avermectin B1 Monosaccharide and Avermectin B_1 Aglycone

作　　者：吴庆安[1] 徐振元[1] 郑鹛[1] 许丹倩[1] 陈正晖[1] 沈寅初[1] 

机构地区：[1]浙江工业大学化工与材料学院,杭州310032

出　　处：《农药》2004年第1期28-29,共2页Agrochemicals

摘　　要：在H2SO4浓度分别为5%(v/v)和10% (v/v)的THF-H2O溶液中对阿维菌素B1(Ⅰ)进行水解,相应得到了单糖AVM B1(Ⅱ)和无糖AVM B1(Ⅲ);向反应体系中加入0.4%(mol/mol)的四丁基溴化铵后,(Ⅲ)的收率由原来的50%提高到60.6%;通过改用混合溶剂萃取和增加盐水洗涤步骤,消除了后处理过程中出现的乳化现象,顺利地实现了分离。Avermectin B1 monosaccharide (Ⅱ) and avermectin B1 aglycone (Ⅲ) were prepared by hydrolysis of avermectin B1(Ⅰ) in THF-H2O with 5% and 10% (v/ v) H2SO4, respectively. The yield of the aglycone was increased from 50% to 60.6% byusing tetrabutyl ammonium bromide as a phase transfer catalyst. The emulsion formation during the separation process wastreated by extracting with a solvent mixture and washing with aqueous NaCl.

关 键 词：催化水解法 制备 单糖阿维菌素B1 无糖阿维菌素B1 杀虫剂 

分 类 号：TQ455[化学工程—农药化工]