血清胱蛋白C对早期糖尿病肾病的诊断价值  

Significance of serum cystatin C concentration in diagnosis of early diabetic nephropathy

作　　者：卞鲁岩[1] 夏平[1] 

机构地区：[1]青岛市市立医院肾内科,山东青岛266071

出　　处：《实用医药杂志》2003年第12期896-897,共2页Practical Journal of Medicine & Pharmacy

摘　　要：目的寻找一种更为简便的诊断早期糖尿病肾病的方法。方法采用颗粒增强透射免疫比浊法(PENIA)测定67例糖尿病(DM)病人的血清胱蛋白C(Cysc)浓度,同时测定白蛋白排泄率(UAE)作为对照,以判断血清胱蛋白C浓度在早期糖尿病肾病中的临床意义及应用价值。结果UAE升高组(早期糖尿病肾病组)的血清Cysc浓度均较UAE正常组明显升高(P<0.01),与尿β2微球蛋白(β2-MG)浓度呈正相关,与肌酐清除率(Ccr)呈负相关。结论血清Cysc浓度升高可作为诊断早期糖尿病肾病的一项指标,它和UAE有相同的临床意义,并且简便易行。Objective To study a simple method for diagnosis of early diabetic nephropathy.Methods Serum cystatin C concentration and urinary albumin excretion(UAE)were measured in67patients with diabetes mellitus by particle-enhanced turbidimetric immunoassay.Relationship between the two parameters was evaluated.Results Serum cystatin C was positively correlated with urinary albumin excretion orβ2microglobulin,and negatively correlated with creatinine clear rate(Ccr).Conclusion Serum cystatin C is a useful indicator for diagnosis of early diabetic nephropathy,simpler and feasibler than urinary albumin excretion.

关 键 词：血清胱蛋白C 尿白蛋白排泄率 早期糖尿病肾病 

分 类 号：R446.112[医药卫生—诊断学] R587.1[医药卫生—临床医学]