杏桔合剂辅助治疗慢性阻塞性肺疾病急性加重期患者疗效分析  

Curative effect of apricot orange mixture in the auxiliary treatment of patients with acute exacerbation period of chronic obstructive pulmonary disease

作　　者：王沁[1] 

机构地区：[1]南京市中医院肺病科,江苏南京210001

出　　处：《新乡医学院学报》2016年第12期1078-1081,共4页Journal of Xinxiang Medical University

摘　　要：目的观察杏桔合剂辅助治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效及安全性。方法将2015年1月至2016年1月收治的AECOPD患者40例分为杏桔合剂组和常规治疗组,每组20例。2组患者均给予AECOPD常规治疗,杏桔合剂组患者加用杏桔合剂治疗,疗程7 d。分析治疗前后临床症状积分判定疗效,比较静脉血白细胞计数(WBC)、中性粒细胞百分比(N)、超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)、动脉血氧分压(Pa O2)和动脉血二氧化碳分压(Pa CO2)等指标的变化,选择静脉血丙氨酰氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、尿素氮(BUN)、血清肌酐(SCr)评估用药安全性。结果杏桔合剂组和常规治疗组患者治疗后总有效率分别为90.0%(18/20)、85.0%(17/20),2组患者治疗后总有效率比较差异无统计学意义(P>0.05)。与治疗前比较,治疗后第3、5、7天2组患者主要临床症状(咳嗽、痰量、气喘)积分均显著下降(P<0.01);与常规治疗组比较,杏桔合剂组患者在治疗中各观察时间点的咳嗽积分均显著下降(P<0.05),但痰量和气喘积分各观察时间点比较差异无统计学意义(P>0.05)。2组患者治疗后WBC、N、hs-CRP、PCT均较治疗前显著下降,且随治疗时间的延长下降越显著(P<0.01);与常规治疗组比较,杏桔合剂组患者在治疗第3、7天时WBC、N、hs-CRP下降较显著(P<0.05)。2组患者治疗后Pa O2均较治疗前显著升高(P<0.05),Pa CO2治疗前后比较差异无统计学意义(P>0.05);2组患者治疗后Pa O2、Pa CO2比较差异均无统计学意义(P>0.05);2组患者治疗前后ALT/AST、BUN、SCr以及组间比较差异均无统计学意义(P>0.05)。结论杏桔合剂虽不能提高AECOPD患者总疗效,但可快速改善咳嗽,治疗中未见明显肝肾毒性,其作用机制可能通过辅助改善炎症起作用。Objective To observe the clinical efficacy and safety of apricot orange mixture in the auxiliary treatment of patients with acute exacerbation of chronic obstructive pulmonary disease( AECOPD). Methods Forty patients with AECOPD in Nanjing Hospital of Traditional Chinese Medicine from January 2015 to January 2016 were randomly divided into apricot orange mixture group and conventional treatment group. All patients were given AECOPD routine treatment. In addition,the patents in apricot orange mixture group were given apricot orange mixture treatment for 7 days. Curative effect was analyzed by comparing the clinical curative effect score before and after treatment. The indexes of white blood cell count( WBC),neutrophils percentage( N),hypersensitive C-reactive protein( hs-CRP),procalcitonin( PCT),partial pressure of oxygen( Pa O2)and partial pressure of carbon dioxide( Pa CO2) were compared. The indexes of alanine aminotransferase( ALT),aspartate aminotransferase( AST),urea nitrogen( BUN) and serum creatinine( SCr) were choose for evaluating the clinical safety of treatment. Results The total effective rate of patients in apricot orange mixture group and conventional treatment group was90. 0%( 18/20) and 85. 0%( 17/20) respectively after treatment; there was no statistic difference of the total effective rate between the two groups( P > 0. 05). The main clinical symptoms( cough,phlegm,asthma) scores of patients at 3,5,7 days after treatment were significantly lower than before treatment in the two groups( P < 0. 01). Compared with the conventional treatment group,the cough scores of patients in apricot orange mixture group were decreased at each observation time point( P < 0. 05). There were no statistic difference of phlegm and asthma scores of patients at each observation time point betweenthe two groups( P > 0. 05). The WBC,N,hs-CRP and PCT of patients after treatment were significantly lower than before treatment in the two groups( P < 0. 01),and the difference was more significant with the increase of treatmen

关 键 词：慢性阻塞性肺疾病 杏桔合剂 肺功能 呼吸系统 

分 类 号：R563.9[医药卫生—呼吸系统]