阿托伐他汀与氟伐他汀治疗高胆固醇血症的对比研究  

Comparative study of atorvastatin and fluvastatin in treatment of hypercholesterolemia

作　　者：谢黎崖[1] 张黎静[1] 

机构地区：[1]福建医科大学附属厦门第一医院,361003

出　　处：《中国基层医药》2003年第12期1260-1261,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　探讨阿托伐他汀 (立普妥 )与氟伐他汀 (来适可 )对高胆固醇血症病人疗效及安全性。方法　 10 0例高胆固醇血症随机分成阿托伐他汀组 5 0例和氟伐他汀组 5 0例 ,治疗 6周后观察比较。结果　阿托伐他汀及氟伐他汀均能明显降低TC、TG、LDL C水平 (P <0 0 1或P <0 0 5 ) ,阿托伐他汀降TC、TG、LDL C的作用强于氟伐他汀 (P <0 0 5 ) ,两药均能升高HDL C水平 (P <0 0 5 ) ,但两组比较未达到显著差异 (P >0 0 5 )。两药不良反应均比较小 ,耐受性好。结论　阿托伐他汀降TC、TG、LDL C的作用优于氟伐他汀 ,但升高HDL C水平相似 ,两药均有良好的安全性。Objective To study the clinical efficacy and safety of atorvastatin(lipitor) and fluvastatin(lescol) on hypercholesterolemia.Methods One hundred patients with hypercholestrolemia were divided into atorvastatin group(n=50) and fluvastatin group(n=50).The lipid and safety was studied after treatment for 6 weeks.Results Atorvastatin and fluvastatin could significantly reduced the levels of TC,TG,LDL-C(P<0.01 or P<0.05).Atorvastatin was better than fluvastatin in reducing TC,TG,LDL-C(P<0.05).Both agents increased HDL-C(P<0.05) without significant difference between two groups.Both agents had little side-effect and good tolerance.Conclusion Atorvastatin is better than fluvastatin in reducing the levels of TC,TG,LDL-C,but is similary in increasing HDL-C.Both agents have good reliability.

关 键 词：阿托伐他汀 氟伐他汀 治疗 高胆固醇血症 他汀类药物 

分 类 号：R589.2[医药卫生—内分泌]