Tunable gold nanostar synthesis with surfactant-free system  

采用无表面活性剂体系合成不同形貌金纳米星（英文）

作　　者：Xupeng Yang Zhenzhen Yang Lu Zhang Qi Sun Xianrong Qi 杨绪朋;仰浈臻;张泸;孙琪;齐宪荣(北京大学医学部药学院药剂学系分子药剂学与新释药系统北京市重点实验室)

机构地区：[1]Department of Pharmaceutics,School of Pharmaceutical Sciences,Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System,Peking University Health Science Center,Beijing 100191,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2019年第9期641-649,共9页中国药学（英文版）

基　　金：National Nature Science Foundation of China(Grant No.81673365,81803459)

摘　　要：Gold nanoparticle is an important photothermal conversion material in photothermal imaging and photothermal therapy research.There are diverse gold nanoparticles,including gold nanospheres,gold nanorods,gold nanocages,gold nanoshells and gold nanostars.Among them,gold nanostar(AuNS)possesses more excellent prospective imaging contrast agent for cancer diagnosis than other shapes of gold nanoparticles because of its larger photon interception area and cross section as well as scattering characteristics.The properties of AuNS are susceptible to synthetic methods and conditions.In this study,we presented surfactant-free methods to synthesize AuNS,discussed the relationship of AuNS characterization with the synthetic conditions and tested its photothermal effect.The results indicated that length and number of branches in AuNSs were the main factor for absorption wavelength in photothermal conversion,and the Au NSs could be more precisely controlled by changing the synthesis conditions.金纳米粒子是一种被用于光热成像和光热治疗研究重要的光热转换材料。已经有各种各样的金纳米粒子被开发出来,包括金纳米球,金纳米棒,金纳米笼,金纳米壳和金纳米棒。其中,金纳米星(AuNS)因其较大的光子截留面积和横截面以及散射特性而具有比其他形状的金纳米粒子更优异的用于癌症诊断的前瞻性成像造影剂。AuNS的性质易受合成方法和条件的影响。在这项研究中,我们提出了无表面活性剂合成AuNS的方法,并讨论了AuNS表征与合成条件的关系并检验了其光热效应。结果表明,AuNS中分支的长度和数量是光热转换中吸收波长的主要因素,通过改变合成条件可以更精确地控制AuNS。

关 键 词：AuNS synthesis SURFACTANT-FREE Tunable properties 

分 类 号：R943[医药卫生—药剂学] TB383.1[医药卫生—药学]